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Lower levels of Gαq — a protein that regulates many aspects of immune responses — appear to drive the progression of primary Sjogren’s syndrome by increasing a subset of pro-inflammatory immune cells, a study shows.  The study, “Expression of Gαq Is Decreased in Lymphocytes from Primary Sjogren’s Syndrome…

Patients with primary Sjögren’s syndrome whose first symptoms are not mouth and eye dryness may experience more progressive and severe pulmonary manifestations during the course of their disease, a study reports. The study, “Interstitial lung disease in non-sicca onset primary Sjögren’s syndrome: a large-scale case-control study,” appeared…

Healthy gut microbial communities — its microbiota — can ease Sjögren’s syndrome-associated symptoms and immune responses, according to a study in a mouse model of the disease. These results show a protective role of the gut’s microbiota, and one could serve to develop new therapies for Sjögren’s patients. The study,…

Individuals with dry mouth, including those with Sjögren syndrome, may benefit from using a moisturizing mouthwash with cetylpyridinium chloride, a new study shows. The study, “A randomized controlled study to evaluate an experimental moisturizing mouthwash formulation in participants experiencing dry mouth symptoms,” was published in the journal Oral Surgery, Oral…

Severe muscle weakness in all four limbs may be a symptom of Sjögren’s syndrome, a case report contends. Researchers hope their study will increase awareness about the multitude of ways Sjögren’s syndrome may be recognized, and subsequently improving the diagnosis. The study, “Complete Hypokalemic Quadriparesis as a…

Neurological symptoms, including paralysis, experienced by Sjögren’s syndrome patients may not be caused by the disease but rather by mental disorders for which psychotherapy may be a better treatment option, a case report suggests. The study, “Systemic Lupus Erythematosus and Sjögren’s Syndrome…

Cerebellar atrophy — the deterioration of nerve cells in the cerebellum — is a rare but serious manifestation of primary Sjogren’s syndrome, according to a new case study from Iran. The report, “Cerebellar degeneration in primary Sjogren syndrome,” was published in the journal BMJ Case Reports. Sjogren’s…

Patients with primary Sjogren’s syndrome (pSS) show altered levels of specific types of immune T-cells and B-cells, which may play an important role in disease activity, new research from Norway suggests. The study, “T follicular-like helper cells in the peripheral blood of patients with primary Sjogren’s…

Although rare, localized amyloidosis can sometimes appear as a consequence of Sjogren’s syndrome, according to a case report from South Korea. The study, “Primary Sjogren syndrome diagnosed simultaneously with localized amyloidosis of the lacrimal gland: A case report,” was published in the journal Medicine. A 45-year-old woman arrived at Pusan National University…

Treatment with interferon-beta (IFN-β) reduces the inflammatory response in immune cells from Sjögren’s syndrome patients, a study reports. The findings suggest that treatment with IFN-β may be a potential way of controlling inflammation in Sjögren’s patients. The study, “…