Childhood-onset Sjögren’s disease can cause lasting damage to the body’s organs by early adulthood, regardless of how active the disease has been or how severely the symptoms have manifested. Those are the findings of a single-center study in the U.K. that investigated the “long-term disease trajectories and complications of…
Note: This story was updated Dec. 17, 2025, to correct that the infiltrations were done in the parotid glands, not the parathyroid. A minimally invasive treatment that involves irrigating the major salivary glands with corticosteroids, a type of anti-inflammatory medication, significantly reduced both objective and subjective measures of dry mouth…
Four genes involved in a form of cell death called pyroptosis are highly active in people with Sjögren’s disease and may serve as disease biomarkers or therapeutic targets, a study reports. By examining the activity of each of the genes — PECAM1, IFI16, AIM2, and MPEG1 —the researchers…
A new artificial intelligence (AI) tool has demonstrated the ability to significantly enhance the diagnosis of Sjögren’s disease by rapidly and accurately analyzing tissue samples, according to a multicenter European study. The AI system achieved an accuracy of more than 87% in classifying the focus score, which is the…
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