A molecule that helps control how genes work, called hsa-miR-661, may help doctors diagnose primary Sjögren’s disease and could one day become a treatment target, according to a study from China. Researchers found that levels of hsa-miR-661 were significantly higher in circulating immune cells taken from people with primary…
Childhood-onset Sjögren’s disease can cause lasting damage to the body’s organs by early adulthood, regardless of how active the disease has been or how severely the symptoms have manifested. Those are the findings of a single-center study in the U.K. that investigated the “long-term disease trajectories and complications of…
Note: This story was updated Dec. 17, 2025, to correct that the infiltrations were done in the parotid glands, not the parathyroid. A minimally invasive treatment that involves irrigating the major salivary glands with corticosteroids, a type of anti-inflammatory medication, significantly reduced both objective and subjective measures of dry mouth…
Four genes involved in a form of cell death called pyroptosis are highly active in people with Sjögren’s disease and may serve as disease biomarkers or therapeutic targets, a study reports. By examining the activity of each of the genes — PECAM1, IFI16, AIM2, and MPEG1 —the researchers…
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