Measuring the protein IL-6 in saliva may aid in diagnosing primary Sjogren’s syndrome (pSS), a study reports. The study, “Association of salivary inflammatory biomarkers with primary Sjögren’s syndrome,” was published in the…
News
Severe dryness symptoms increase the risk of developing tooth cavities and having oral Candida infection in people with Sjögren’s syndrome, a new study found. The study, “Sicca Symptoms, Oral Health Conditions, Salivary Flow…
The University of Queensland’s technology transfer company, UniQuest, will partner with the biotechnology company CSL Limited to develop and commercialize the university’s antigen specific immune tolerance induction (ASITI) technology for the treatment of Sjogren’s syndrome. As an autoimmune disorder, Sjogren’s syndrome involves the immune system…
Luminary Therapeutics will collaborate with researchers at Case Western Reserve University to develop a new form of CAR T-cell therapy that uses the B-cell activating factor (BAFF) target as a treatment for Sjogren’s syndrome and mantle cell lymphoma. The…
A new study has uncovered two potential biomarkers of primary Sjögren’s syndrome (pSS): progranulin (PGRN) and Oxford 40 ligand (OX40L). People with pSS have higher levels of these two proteins compared to healthy volunteers. The study, “Clinical Significance of Progranulin Correlated With Serum Soluble Oxford 40 Ligand in Primary Sjögren’s…
Researchers have discovered the mechanisms by which Bcl-6 — a protein that is considered a “master regulator” of the immune system — controls the activity of a subset of immune T-cells involved in a range of disorders. According to researchers, knowledge of these mechanisms may prompt the development of…
People with primary Sjögren’s syndrome (pSS) have significantly higher levels of CD72 — a regulatory protein on B-cells, a type of immune cell associated with pSS — than healthy peers, according to a study from China. Data also highlighted an association between CD72 levels and those of IgG —…
A Phase 4 clinical trial evaluating Wize Pharma‘s LO2A eye drops as a treatment for dry eye symptoms in people with Sjögren’s syndrome has been completed, the company announced. Results from the trial are expected later this year, though they may be delayed due to the ongoing…
Genetic variations in the complement system — a part of the immune response — contribute to differences between men and women in their susceptibility to Sjögren’s syndrome, lupus, and schizophrenia, according to a study. In particular, the study showed that higher levels of complement component 4…
A small RNA molecule may help to drive inflammation in the eyes of people with primary Sjögren’s syndrome (pSS), a new study reports. The findings imply that this molecule, called miR-744-5p, may be a therapeutic target for pSS. The study, “miR-744-5p contributes to ocular inflammation in…
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