A study in Korean patients found five new gene variants associated with the development of Sjögren’s syndrome, which may provide biomarkers for precision medicine, the scientists said. The research, “Variants at potential loci associated with Sjogren’s syndrome in Koreans: A genetic association study,” appeared in the journal…
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A non-invasive assessment of salivary gland damage by ultrasound may be added to current criteria for primary Sjögren’s syndrome (pSS) diagnosis without lowering their accuracy, according to a large clinical practice study. The inexpensive assessment may replace invasive tests that are unavailable in some centers, which improves the feasibility…
Routine examinations of patients with primary Sjögren’s syndrome should include cognitive function tests to assess the presence of impairments, a review study recommends. The study, “Cognitive Function in Primary Sjögren’s Syndrome: A Systematic Review,” was published in Brain Sciences. Sjögren’s syndrome is a chronic autoimmune disease characterized…
Psychiatric disorders including depression, anxiety, and sleep problems are more commonly diagnosed in people with primary Sjögren’s syndrome than in the general population or in those with another rheumatic condition, a study found. Titled, “Increased risks of psychiatric disorders in patients with primary Sjögren’s syndrome —…
Rare diseases deeply affect not only the children who experience them, but also their healthy brothers and sisters, as their parents can attest. Two entries in November’s “Disorder: The Rare Disease Film Festival” will focus on what siblings go through, according to the San Francisco festival’s co-founder,…
Developing gene therapies for rare diseases is one thing. Creating gene-edited “designer babies” is quite another. German legal expert Timo Minssen outlined the potentially explosive ethical landmines surrounding such issues during a recent talk at the New York Genome Center. Minssen directs the Center for Advanced Studies in…
People with primary Sjögren’s syndrome have a distinct protein composition in their tears and saliva when compared to samples from healthy individuals or those with sicca symptoms, whose dryness is not caused by Sjögren’s, a study found. These proteins may serve as biomarkers for non-invasive and fairly easy tests…
Higher levels of some inflammatory signaling molecules are associated with less fatigue in people with primary Sjögren’s syndrome, challenging prior thoughts that inflammatory molecules directly mediate fatigue in chronic autoimmune conditions, a recent validation study found. The study, “Fatigue in primary Sjögren’s syndrome (pSS) is associated with…
Imagine living your whole life with a painful disease so rare that only 25 others worldwide have what you have. And that you’re one of just six such people who’ve made it to adulthood. Neena Nizar doesn’t have to imagine. The 41-year-old English professor at Metro Community College in Elkhorn,…
Analyzing subsets of immune cells in the salivary gland by examining the cells’ epigenetic makeup is a viable way to measure inflammation that may aid in diagnosing and monitoring people with Sjögren’s syndrome, a study suggests. These data were reported in the journal Rheumatology in the paper, “…
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