Note: This story was updated Oct. 1, 2024, to clarify that Sjögren’s is a systemic disease, meaning it can affect moisture-producing glands, as well as other parts of the body. Ainos is planning to launch a Phase 3 clinical trial in Taiwan before the year’s end to evaluate the…
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Topical application of the experimental therapy RCI001 prevented dry eye damage and improved tear secretion in a mouse model of Sjögren’s disease, according to a new study. Treatment in the mice also reduced markers of inflammation and oxidative stress, a type of cellular damage implicated in eye surface inflammation…
Dental implants for women with primary Sjögren’s disease — who commonly experience problems with their teeth due to dry mouth — appear to work well and improve quality of life over five years, with gum health and appearance similar to women without the disease, a new study found. According to…
Lip salivary gland biopsy using an auxiliary device called chalazion forceps may diagnose primary Sjögren’s disease as accurately as the conventional method, but with fewer procedure-related complications, a study suggests. Researchers noted that, compared with the conventional method, “the modified [lip salivary gland biopsy] … offers a good safety…
A mutation in the TNIP1 gene resulted in a chronic autoimmune disease for two people, one of whom had symptoms similar to Sjögren’s disease, a study shows. The other patient had symptoms of systemic lupus erythematosus (SLE), another type of autoimmune disease. Experiments in mice with the mutation,…
Women with primary Sjögren’s syndrome are more likely to give birth prematurely and have babies born with congenital heart block (CHB) — a condition that disrupts the transmission of electrical signals within the heart needed to maintain a normal heartbeat — than women with other autoimmune conditions, a study…
Changes in the metabolic activity of certain immune cells may help to drive the inflammatory attacks that cause Sjögren’s syndrome, a recent study reported. According to its researchers, these findings suggest that targeting a specific metabolic pathway in immune cells, called aerobic glycolysis, may help to reduce disease activity…
The proteins CTSS and GSTO1 could accurately distinguish people with primary Sjögren’s syndrome from unaffected individuals, a study suggests, meaning they show promise as diagnostic biomarkers and possible therapeutic targets for Sjögren’s. “These insights may lead to the development of targeted therapies and improved management strategies for individuals living…
Lip salivary gland biopsy may not be predictive of a Sjögren’s syndrome diagnosis, particularly when it’s based on tissue samples classified as showing a low level of inflammation and damage, according to a study. In 16% of the cases assessed in the study, different pathology teams would draw different conclusions…
Kiniksa Pharmaceuticals has launched a Phase 2b clinical trial to test its injectable therapy abiprubart against a placebo in people with Sjögren’s syndrome. The trial, mainly designed to assess the treatment’s effects on disease severity, is expected to involve about 201 Sjögren’s patients. Kiniksa reports that the trial…
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