A naturally occurring molecule that has the ability to regulate gene activity may represent a promising therapeutic target for Sjögren’s disease and other autoimmune conditions, according to a study. Mimicking the activity of the molecule, miR-216a-3p, eased inflammation and scarring in a rat model of the disease. Its therapeutic…
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More severe salivary gland damage and lymph node enlargement detected by ultrasound examination are associated with higher disease activity in primary Sjögren’s disease, a study in South Korea reports. Also, researchers found that more severe salivary gland damage was tied to a higher prevalence of laboratory risk factors for…
April is Sjögren’s Awareness Month, and a U.S.-based nonprofit is gearing up to help the community spread the word about Sjögren’s disease — and the many ways people impacted by this autoimmune condition can get involved. For this year’s awareness month, the Sjögren’s Foundation is inviting supporters…
Nipocalimab, an experimental antibody-based therapy being developed by Johnson & Johnson, was granted fast track status by the U.S. Food and Drug Administration (FDA) for adults with moderate to severe Sjögren’s disease. Fast track status is given to candidate therapies for serious health conditions with the…
Nearly 80% of women with Sjögren’s disease experience sexual dysfunction, with common symptoms including vaginal dryness, lower sexual satisfaction, and difficulty with arousal, a Chinese study finds. The findings highlight the need of “increased awareness and recognition of sexual health in clinical practice,” the researchers wrote, adding that “policymakers…
People with primary Sjögren’s disease diagnosed at a younger age and who harbor certain self-reactive antibodies are more likely to have kidney involvement, a study in South Korea suggests. While most with kidney involvement were asymptomatic, about a third had impaired kidney function when they were diagnosed and 25%…
About 2 in 3 women and men with Sjögren’s disease experience challenges in their sexual lives that go beyond physical symptoms, such as vaginal dryness or difficulty getting and keeping an erection, and these may include stress, social taboos, and poor body image, a study finds. Physical and emotional…
More than half of women with Sjögren’s disease show loss of bone tissue, or bone erosion, according to a study carried out in Brazil. Findings also showed the volume of bone erosion increased by 7% per year, and was 3.5 times higher for women who had gone through menopause.
A woman with Sjögren’s disease was the first to receive an experimental cell therapy for xerostomia, or severe dry mouth, in a clinical trial at the University of Wisconsin (UW). As part of the Phase 1 study (NCT06392711), six patients are receiving one injection of their own mesenchymal…
A rare condition called cerebral venous thrombosis or CVT, characterized by blood clots forming in veins in the brain, can occur in people with primary Sjögren’s disease, a new study reports. The findings suggest that Sjögren’s patients with co-occurring CVT don’t always show well-known Sjögren’s symptoms, such as dry…
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