Kiniksa Pharmaceuticals has launched a Phase 2b clinical trial to test its injectable therapy abiprubart against a placebo in people with Sjögren’s syndrome. The trial, mainly designed to assess the treatment’s effects on disease severity, is expected to involve about 201 Sjögren’s patients. Kiniksa reports that the trial…
World Sjögren’s Day is held every July 23, the birthday of Henrik Sjögren, the Swedish ophthalmologist who first identified Sjögren’s syndrome in 1933, and this year, to observe the 40th anniversary of the Sjögren’s Foundation, Amgen has pledged a dollar-to-dollar match up to $40,000, meaning donations supporting…
A new photo-detection method was able to accurately and quantitatively measure lactoferrin levels in the tears of people with dry eye disease (DED) associated with Sjögren’s syndrome or other conditions, a study shows. The method also let researchers distinguish patients with DED caused by Sjögren’s from other DED…
The oral microbiome — the community of bacteria living in the mouth — of people with primary Sjögren’s syndrome (pSS) includes a large number of bacteria linked to inflammation and dental caries, or cavities, as well as bacteria that facilitate the colonization of the oral mucosa by other disease-causing…
Introducing immunosuppressive or biological therapies early in people with Sjögren’s syndrome may prevent its progression to a bodywide systemic condition, a study in France suggests. “In our study, we can see that the introduction of [immunosuppressive agents] or biotherapy in systemic forms is only effective in around 50% of…
Older age, smoking, and a condition called Raynaud’s phenomenon are risk factors for developing interstitial lung disease (ILD) among people with primary Sjögren’s syndrome, according to a recent study. The study, “Interstitial lung disease and associated factors in patients with Sjögren’s syndrome,” was published in the…
To help shed light on what it’s like to live with Sjögren’s syndrome, a systemic autoimmune condition thought to affect about 4 million U.S. residents, this year’s Sjogren’s Awareness Month will focus on stories from the patients themselves. The annual April event is designed to showcase the disorder and…
Patients with primary Sjögren’s syndrome who have extra-glandular symptoms have higher levels of the chemokine CXCL9 than those only affected in the saliva and tear-producing glands, a study finds. CXCL9 is a small signaling molecule involved in the migration and maturation of lymphocytes, a type of immune cell thought…
The incidence of breast cancer is higher in women with primary Sjögren’s syndrome than the general population, a study from Taiwan indicates. Diabetes and high levels of anti-SSA autoantibodies were associated with a higher risk of developing breast cancer, according to “…
In adults with Sjögren’s syndrome with missing teeth, implant-supported overdentures — which are removable dentures that rest on implants — may improve the ability to chew, potentially leading to better quality of life, a study has found. The study, “Implant supported overdentures in Sjögren’s disease patients: a multicentre…
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