Drinking a traditional Chinese medicinal tea led to improvements in tear production, reductions in ocular dryness, and better sleep quality in patients with Sjögren’s disease, a study shows. Sjögren’s patients also reported a significant reduction in using artificial tears, from a…
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Johnson & Johnson’s antibody-based therapy candidate nipocalimab has been granted breakthrough therapy designation by the U.S. Food and Drug Administration (FDA) for treating adults with moderate to severe Sjögren’s disease. This status is meant to accelerate the development and regulatory review of investigational therapies intended to treat serious…
Blood levels of antibodies against aquaporin 5 (anti-AQP5) — a protein that regulates water movement in tissues — may be used as a biomarker to diagnose primary Sjögren’s disease, a study…
Blood levels of transthyretin (TTR) may be used as a biomarker to predict and monitor disease activity in people with primary Sjögren’s disease, a study in China suggests. TTR is a protein that transports thyroxine, the main hormone secreted by the thyroid gland, to the liver and brain. It’s…
A web-based tool to assess daily symptoms of Sjögren’s disease is easy to implement, was well accepted, and effectively captures the high day-to-day symptom variability among patients, a three-month pilot study shows. Data collected with the web app PEPSS over a pre-specified period differed from that captured with standard,…
KB-7898, Kronos Bio’s investigational therapy for Sjögren’s disease, was shown to lower antibody production and the release of inflammatory molecules in lab studies involving cell and animal models of autoimmune conditions, the company announced. Kronos is planning further preclinical studies to assess KB-7898’s safety and pharmacological properties…
An imaging test that measures damage to salivary glands may effectively be used, together with the presence of self-reactive antibodies, to diagnose Sjögren’s disease and determine disease staging. That’s according to a new study from China that investigated the use of the imaging test, called parotid sialography, alongside one…
Note: This story was updated Oct. 1, 2024, to clarify that Sjögren’s is a systemic disease, meaning it can affect moisture-producing glands, as well as other parts of the body. Ainos is planning to launch a Phase 3 clinical trial in Taiwan before the year’s end to evaluate the…
Topical application of the experimental therapy RCI001 prevented dry eye damage and improved tear secretion in a mouse model of Sjögren’s disease, according to a new study. Treatment in the mice also reduced markers of inflammation and oxidative stress, a type of cellular damage implicated in eye surface inflammation…
Dental implants for women with primary Sjögren’s disease — who commonly experience problems with their teeth due to dry mouth — appear to work well and improve quality of life over five years, with gum health and appearance similar to women without the disease, a new study found. According to…
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