News

Anti-SSB antibodies may be a predictor of decreased lung function in people with primary Sjögren’s disease who also have interstitial lung disease (ILD), a group of conditions marked by inflammation and scarring in the lungs, according to a retrospective study from Romania. Particularly, the presence of these autoantibodies was…

Certain immune cell types are dysregulated in people with primary Sjögren’s disease, according to a new study from researchers in China that points to the resulting alterations as possible drivers of the condition and factors influencing its severity. “Our study demonstrates significant alterations in circulating immune cell populations in…

Using artificial intelligence (AI) to analyze biopsies of the salivary glands in people with Sjögren’s disease may help identify patients who are likely to have disease involvement in vital organs, a new study reports. According to the researchers, the novel model developed by the team “achieves high accuracy in…

People with Sjögren’s disease tend to have poor oral health relative to the general population, despite generally good hygiene practices, a study found. Sjögren’s was associated with tooth decay, cavities, and wear, ultimately requiring more procedures to restore teeth. Hyposalivation, a common Sjögren’s disease symptom in which the…

Efgartigimod is entering a Phase 3 clinical trial after data from a proof-of-concept Phase 2 trial showed it outperformed a placebo at easing symptoms and signs of primary Sjögren’s disease, the treatment’s developer said. Argenx shared the data at the European Congress of Rheumatology (EULAR) 2025, held June…

Newborns of mothers with primary Sjögren’s disease may be at a higher risk of developing heart conditions. That’s according to a study in China, which also found this increased risk was significantly associated with higher maternal disease activity. “Maternal [primary Sjögren’s], especially with high disease activity, elevates the risk…

A study found significant associations between eye surface changes and alterations in immune activity throughout the body in people with primary Sjögren’s disease. “These results provide new insights into the relationship between ocular surface and systemic [whole body] status in patients with [primary Sjögren’s disease],” the researchers wrote. The study,…

People with Sjögren’s disease are at higher risk of developing non-Hodgkin lymphoma (NHL), a type of blood cancer, as well as other malignancies, a study reports. Researchers also identified several risk factors associated with cancer development in Sjögren’s patients, noting that nearly a quarter of deaths seen among…

Using stem cell eye drops — ones containing mesenchymal stem cells, or MSCs, which can give rise to other cell types — was shown to ease the signs and symptoms of refractory, or hard-to-treat, dry eye disease in adults with and without Sjögren’s disease, according to new data from…

Cullinan Therapeutics is planning the launch of a clinical trial in the U.S. to test its treatment candidate CLN-978 in people with Sjögren’s disease. The study will be open to Sjögren’s patients whose disease is active and moderate to severe, and who are positive for anti-SSA/Ro antibodies and/or…