News

The disruption of the junctions that keep blood vessel cells tightly attached may contribute to the lack of saliva and the high infiltration of immune cells in the salivary glands in Sjogren’s syndrome, a mouse study suggests. The study, “Disruption of endothelial barrier function is linked with hyposecretion and lymphocytic infiltration in…

A subtype of rheumatoid factor targeting a class of antibody called immunoglobulin A can be used as a diagnostic and predictive marker for primary Sjogren’s syndrome, a new study shows. The study, “Clinical and diagnostic significance of serum immunoglobulin A rheumatoid factor in primary Sjogren’s syndrome,” was published in…

Women with primary Sjögren’s syndrome (pSS) do not need to follow specific dietary guidelines to  maintain good nutrition and oral health, a Norwegian study suggests. Furthermore, the patients adequately follow the recommended dietary intakes, which do not seem to influence salivary secretion, the…

Lower levels of Gαq — a protein that regulates many aspects of immune responses — appear to drive the progression of primary Sjogren’s syndrome by increasing a subset of pro-inflammatory immune cells, a study shows.  The study, “Expression of Gαq Is Decreased in Lymphocytes from Primary Sjogren’s Syndrome…

Patients with primary Sjögren’s syndrome whose first symptoms are not mouth and eye dryness may experience more progressive and severe pulmonary manifestations during the course of their disease, a study reports. The study, “Interstitial lung disease in non-sicca onset primary Sjögren’s syndrome: a large-scale case-control study,” appeared…

Healthy gut microbial communities — its microbiota — can ease Sjögren’s syndrome-associated symptoms and immune responses, according to a study in a mouse model of the disease. These results show a protective role of the gut’s microbiota, and one could serve to develop new therapies for Sjögren’s patients. The study,…

Individuals with dry mouth, including those with Sjögren syndrome, may benefit from using a moisturizing mouthwash with cetylpyridinium chloride, a new study shows. The study, “A randomized controlled study to evaluate an experimental moisturizing mouthwash formulation in participants experiencing dry mouth symptoms,” was published in the journal Oral Surgery, Oral…

Severe muscle weakness in all four limbs may be a symptom of Sjögren’s syndrome, a case report contends. Researchers hope their study will increase awareness about the multitude of ways Sjögren’s syndrome may be recognized, and subsequently improving the diagnosis. The study, “Complete Hypokalemic Quadriparesis as a…

Neurological symptoms, including paralysis, experienced by Sjögren’s syndrome patients may not be caused by the disease but rather by mental disorders for which psychotherapy may be a better treatment option, a case report suggests. The study, “Systemic Lupus Erythematosus and Sjögren’s Syndrome…

Cerebellar atrophy — the deterioration of nerve cells in the cerebellum — is a rare but serious manifestation of primary Sjogren’s syndrome, according to a new case study from Iran. The report, “Cerebellar degeneration in primary Sjogren syndrome,” was published in the journal BMJ Case Reports. Sjogren’s…