News

Abnormal marginal zone B (MZB)-cells in the lacrimal glands of the eye appear to drive the production of autoantibodies and cause the chronic “dry eye” symptoms patients with Sjogren’s syndrome experience, a study in mice suggests. The research, “Dysregulated Marginal Zone B Cell Compartment in a Mouse…

While rare, patients with primary Sjogren’s syndrome can develop central nervous system disease due to involvement of large blood vessels, rather than small or medium-sized blood vessels, according to a new case study. The study, “Cerebral Large-Vessel Vasculitis in Sjogren’s Syndrome: Utility of High-Resolution Magnetic Resonance Vessel Wall Imaging,”…

Compounds known as glucosides, extracted from the root of a flower called the Chinese peony, alleviated dryness, lessened fatigue, and reduced overall disease burden in Sjögren’s syndrome patients, a randomized trial in China shows. Trial findings were published in the study, “The efficacy and safety of…

Dental implants with fitted crowns provided comfort and relieved inflammation in a Sjögren’s syndrome patient experiencing discomfort with removable dentures, according to a case report from dental surgeons in Japan. The report, “Implant-supported Prostheses in Patient with Sjögren’s Syndrome: Clinical Report with 3-year Follow-up,” was published in the…

Levels of BST-2 — a molecule involved in fighting virus infections — in salivary glands correlate with disease activity in patients with primary Sjögren’s syndrome, and may serve as a biomarker for diagnosing the condition, a study suggests. The study, “Aberrant expression of the innate restriction factor bone…

Half a year has gone by since disgraced pharma executive Martin Shkreli was sentenced to seven years in federal prison for securities and wire fraud while heading San Diego-based Retrophin. As founder and CEO of another company (then known as Turing Pharmaceuticals), in late 2015 Shkreli bought the rights…

Sjögren’s syndrome patients are more likely to experience both aortic aneurysms and aortic dissection — two medical complications that affect the wall of the aorta, the largest blood vessel in the body that carries blood from the heart to the rest of the body. The study with that finding,…

Cyclosporine A treatment improves vision and increases tear production in people with moderate-to-severe dry eye disease, including those with Sjögren’s syndrome, an Egyptian study shows. The research, “Efficacy and safety of using topical cyclosporine A for treatment of moderate to severe dry eye disease,” was published in…

Physicians in Cincinnati have reported the rare case of a woman whose first symptom of primary Sjögren’s syndrome was intracranial bleeding. While rare — only two similar cases have been described to date — increasing awareness about the neurological manifestations of the disease could lead to prompt treatment of these…

More than 700 medical experts, pharmaceutical executives, patient advocates, and others are expected to converge on Washington, D.C., next month for the 2018 NORD Rare Diseases & Orphan Products Breakthrough Summit. The Oct. 15-16 event, sponsored by the National Organization for Rare Diseases (NORD), takes place at the…