News

Alterations in salivary glands that cause immune cell infiltration in Sjӧgren’s syndrome patients may be triggered by changes in the mouth’s bacterial composition, findings from a recent study suggest. While many bacterial changes were evident, one particular bacterial species was enough to initiate an inflammatory cascade that contributed in…

Vaginal dryness in women with primary Sjögren’s syndrome may be caused by defective blood vessels and an infiltration of immune cells in their vagina and cervix, a new study suggests. The findings were published in the journal Rheumatology in the study, “Vaginal dryness in primary Sjögren’s…

Seasonal changes do not appear to significantly influence the main symptoms of primary Sjögren’s syndrome — pain, fatigue, and dryness — according to a large study. The study, “Seasonal effect on fatigue, pain and dryness in primary Sjögren’s syndrome,” was published in the journal Arthritis Research…

Poor sleep quality is linked to both fatigue and increased disease activity in primary Sjögren’s syndrome patients, a study reported. Its researchers recommend more study into ways that might help patients with difficulty sleeping, a common problem in this disease. The study, “Correlation of sleep quality with fatigue and disease activity…

People with primary Sjögren’s syndrome who have symptoms outside their glands may carry a higher risk of developing other conditions, such as heart or thyroid disease, and might also be more prone to fractures, according to a study. The findings suggest that making the evaluation of these additional conditions…

The immune cells that produce self-targeting antibodies in cryoglobulinemia vasculitis (CV), a complication of Sjogren’s syndrome, are characterized by mutations that are known to drive lymphomas, a new study suggests. This finding provides clues as to how autoimmune diseases develop, and could open new avenues for diagnosis…

People with primary Sjögren’s syndrome have poor overall and oral health-related quality of life compared to healthy people, but these measures appear to be even worse among those with dryness symptoms (sicca) not related to the disorder, a study has found. The findings suggest that people with non-Sjögren’s…

In recognition of Rare Disease Day Feb. 29, Bionews Services launched a social media campaign last month asking patients to describe what makes them rare. Running Feb. 7–29, the #WhatMakesMeRare campaign was aimed at uplifting people with rare diseases by encouraging them to share their stories and perspectives. The…

Catalpol, the active ingredient in a medicinal herb often used for Sjögren’s syndrome treatment, eases disease symptoms by altering the balance and communication of specific immune cells, a study in mice suggests. The study, “Catalpol ameliorates Sjögren’s Syndrome by modulating interplay of T and B cells,”…

Iscalimab, an investigational antibody therapy from Novartis, showed promise for safety and preliminary efficacy for lessening disease activity in people with primary Sjögren’s syndrome who experience symptoms across the body. Larger and longer studies are warranted to assess the clinically meaningful benefits of the potential therapy, researchers…