News

The arginase 1 protein appears to protect from dryness symptoms associated with Sjögren’s syndrome, potentially by lowering gland inflammation and increasing fluid secretion, a new study in mice indicates. The findings suggest this protein — a liver enzyme — as a possible therapeutic target for this condition. The study,…

Attention deficits may underlie the cognitive impairment that impacts a substantial portion of Sjögren’s syndrome patients with neurological symptoms, according to a new study. Such impairment is likely to affect other cognitive functions, as well as the ability to perform job-related tasks and engage in social activities, the researchers…

The tumor protein CA153 may be a valuable blood biomarker for the early diagnosis and treatment of interstitial lung disease (ILD) in people with primary Sjögren’s syndrome (pSS), a recent study found. The study, “Increases in tumor markers are associated with primary Sjögren’s syndrome-associated interstitial…

High activity levels in immune-related genes are associated with the malfunction of immune cells isolated from people with primary Sjogren’s syndrome, a small study revealed.  Such increased gene activity levels correlate with disease severity, the researchers found. Titled “…

Primary Sjögren’s syndrome (pSS) should be considered in children with unexplained kidney and neurological symptoms, and unexplained fever, a study suggests. In the study, “Nephrological disorders and neurological involvement in pediatric primary Sjogren syndrome: a case report and review of literature,” published in the journal Pediatric…

Measuring the protein IL-6 in saliva may aid in diagnosing primary Sjogren’s syndrome (pSS), a study reports. The study, “Association of salivary inflammatory biomarkers with primary Sjögren’s syndrome,” was published in the…

Severe dryness symptoms increase the risk of developing tooth cavities and having oral Candida infection in people with Sjögren’s syndrome, a new study found. The study, “Sicca Symptoms, Oral Health Conditions, Salivary Flow…

The University of Queensland’s technology transfer company, UniQuest, will partner with the biotechnology company CSL Limited to develop and commercialize the university’s antigen specific immune tolerance induction (ASITI) technology for the treatment of Sjogren’s syndrome. As an autoimmune disorder, Sjogren’s syndrome involves the immune system…

Luminary Therapeutics will collaborate with researchers at Case Western Reserve University to develop a new form of CAR T-cell therapy that uses the B-cell activating factor (BAFF) target as a treatment for Sjogren’s syndrome and mantle cell lymphoma. The…

A new study has uncovered two potential biomarkers of primary Sjögren’s syndrome (pSS): progranulin (PGRN) and Oxford 40 ligand (OX40L). People with pSS have higher levels of these two proteins compared to healthy volunteers. The study, “Clinical Significance of Progranulin Correlated With Serum Soluble Oxford 40 Ligand in Primary Sjögren’s…