A research team in Japan has developed three-dimensional (3D) “mini organs” from human stem cells to model the lacrimal glands, or tear ducts, which are dysfunctional in Sjögren’s syndrome. The first of their kind, these new mini organs, or organoids, can be used in the future to study disease…
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Steroid injections into the spine — similar to the epidural injections often given during childbirth — were effective in controlling pain as a result of nerve damage in a 32-year-old woman with Sjögren’s syndrome, according to a case report. The report, “Lumbar interlaminar epidural steroid injections…
Levels of antibodies that target the nuclear protein HMGB1 are elevated in the bloodstream of adults with Sjögren’s syndrome, a study reported. Detecting anti-HMGB1 antibodies in the blood may support a clinical diagnosis of Sjögren’s syndrome, its researchers suggested. The study, “Anti-HMGB1 antibody is a potential…
Levels of the chemical messenger CCL28 are reduced in the blood of people with primary and secondary Sjögren’s syndrome, and were correlated with oral disease features like dental cavities and salivary gland damage, according to a recent Chinese study. Additionally, blood count changes — also lower — were linked…
Intense pulsed light therapy along with meibomian gland expression (IPL-MGX) significantly eased dry eye symptoms and improved eye health in people with Sjögren’s syndrome, according to a recent study. “Our results indicated that three IPL-MGX sessions could significantly improve the subjective and objective…
NYU Langone Health is joining with a National Institutes of Health (NIH) sponsored program aimed at understanding disease mechanisms and developing new treatments for autoimmune disorders such as Sjögren’s syndrome. The program, called Accelerating Medicines Partnership Autoimmune and Immune-Mediated Diseases (AMP AIM), began last year in an…
This year’s Sjögren’s Awareness Month will focus on patient experiences to share glimpses into the lives of people with Sjögren’s syndrome, a complex disorder that is thought to affect four million U.S. residents. Each day in April, the Sjögren’s Foundation will showcase a different patient on its website and…
The thickness of the eye’s retina and the density of retinal blood vessels are significantly lower in women with Sjögren’s syndrome than healthy women, an imaging study demonstrated. Retinal thinning, as measured by the noninvasive imaging technique called optical coherence tomography angiography (OCTA), may help diagnose Sjögren’s, according to…
Fatigue had the biggest impact on daily activities among people with primary Sjögren’s syndrome and was one of a number of symptoms associated with increased anxiety, depression, and physical limitations, according to a recent U.K. study. This effect was markedly reduced in patients with a longer disease duration, suggesting that…
Dry eye disease is more severe in people with primary Sjögren’s syndrome than in other patients, but their perception of eye discomfort may be altered, according to a recent study. “Clinicians should be aware that [Sjögren’s] patients may complain less of their discomfort” while having a particularly severe case…
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