Add-on treatment with Artiva Biotherapeutics’ experimental cell therapy AlloNK (AB-101) was associated with improvements in symptoms and increased saliva flow at six months in a small group of adults with difficult-to-treat Sjögren’s disease in a basket clinical trial. However, the global Phase 2a study (NCT06991114) is a…
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Amgen’s experimental therapy dazodalibep led to rapid, sustained reductions in disease activity among adults with moderate-to-severe Sjögren’s disease in a global clinical trial, according to top-line data announced by the company. “The results mark an important step forward for people living with Sjögren’s disease, a condition with significant…
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Swelling of the major salivary glands without dry mouth at the time of a Sjögren’s disease diagnosis may point to a distinct disease profile marked by younger age, higher disease activity, and more severe glandular abnormalities, a study from South Korea suggested. “Recognition of this [Sjögren’s] presentation may support…
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Four genes related to an immune signaling protein called interferon-gamma (IFN-gamma) are more active in people with Sjögren’s disease, and measuring their activity levels may help distinguish patients from healthy individuals, a study found. Further analysis pointed to macrophages — immune cells involved in inflammation, tissue repair, and IFN-gamma…
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