Amgen’s experimental therapy dazodalibep led to rapid, sustained reductions in disease activity among adults with moderate-to-severe Sjögren’s disease in a global clinical trial, according to top-line data announced by the company. “The results mark an important step forward for people living with Sjögren’s disease, a condition with significant…
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Swelling of the major salivary glands without dry mouth at the time of a Sjögren’s disease diagnosis may point to a distinct disease profile marked by younger age, higher disease activity, and more severe glandular abnormalities, a study from South Korea suggested. “Recognition of this [Sjögren’s] presentation may support…
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Four genes related to an immune signaling protein called interferon-gamma (IFN-gamma) are more active in people with Sjögren’s disease, and measuring their activity levels may help distinguish patients from healthy individuals, a study found. Further analysis pointed to macrophages — immune cells involved in inflammation, tissue repair, and IFN-gamma…
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A global clinical trial testing the safety and early effectiveness of MRT-6160, an oral treatment for Sjögren’s disease, is now recruiting an estimated 344 adults with the autoimmune condition. The experimental therapy is designed to reduce the activity of two major types of immune cells that help drive Sjögren’s,…
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