Swelling of the major salivary glands without dry mouth at the time of a Sjögren’s disease diagnosis may point to a distinct disease profile marked by younger age, higher disease activity, and more severe glandular abnormalities, a study from South Korea suggested. “Recognition of this [Sjögren’s] presentation may support…
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Four genes related to an immune signaling protein called interferon-gamma (IFN-gamma) are more active in people with Sjögren’s disease, and measuring their activity levels may help distinguish patients from healthy individuals, a study found. Further analysis pointed to macrophages — immune cells involved in inflammation, tissue repair, and IFN-gamma…
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A global clinical trial testing the safety and early effectiveness of MRT-6160, an oral treatment for Sjögren’s disease, is now recruiting an estimated 344 adults with the autoimmune condition. The experimental therapy is designed to reduce the activity of two major types of immune cells that help drive Sjögren’s,…
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Immunosuppressive treatment for Sjögren’s disease-associated interstitial lung disease (ILD) has become more common in recent years, particularly among patients with greater respiratory symptoms or poorer lung function, a European study found. Despite the shift toward more frequent and diverse treatment, the proportion of patients whose lung disease worsened after…
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