Topical application of the experimental therapy RCI001 prevented dry eye damage and improved tear secretion in a mouse model of Sjögren’s disease, according to a new study. Treatment in the mice also reduced markers of inflammation and oxidative stress, a type of cellular damage implicated in eye surface inflammation…

A low dose treatment of interleukin-2 (IL-2), an immune signaling protein, improved salivary gland function in a Sjögren’s syndrome mouse model, but it didn’t reverse immune-mediated structural damage to the glands, a study showed. Although IL-2 may improve salivary gland function in Sjögren’s, combining it with other immunomodulatory therapies…

Mesenchymal stem cells (MSCs) isolated from dental tissue eased the signs and symptoms of Sjögren’s syndrome in a mouse model, a study indicated. These effects were driven by the cells’ ability to modulate immune responses, according to researchers, who noted that MSCs are “rapid proliferating” and have “strong anti-inflammatory…

The activity of certain “clock genes” — those involved in the body’s internal clock, or circadian rhythm — is significantly dysregulated in the salivary glands of people with primary Sjögren’s syndrome (pSS) and a disease mouse model, a study shows. Treatment with melatonin, a hormone that regulates the circadian…

Certain proteins in saliva are found at significantly different levels in mice modeling Sjögren’s syndrome as compared with healthy animals, and may serve as promising biomarkers for the chronic autoimmune disorder, a study found. If the findings are confirmed in humans, they could advance a method to diagnose Sjögren’s using…

The findings of a new study support the development of Incyte‘s parsaclisib as a potential therapy for Sjögren’s syndrome and other autoimmune diseases. Parsaclisib, an oral inhibitor of phosphatidylinositol 3-kinase (PI3K) delta, was found to ease the symptoms of Sjögren’s and other disorders in a study using mouse models.

An accumulation of damaged, pro-inflammatory immune cells, called senescence-associated T-cells, in salivary glands likely underlies gland dysfunction and dry mouth symptoms commonly seen with aging and in Sjögren’s syndrome patients, a study in mice suggests. Notably, this senescent T-cell buildup was found to be associated with an increased production…

Oral treatment with a molecule produced by bacteria, called colonization factor antigen I, can reduce or halt the progression of Sjögren’s syndrome, a mouse study suggests. Researchers believe these findings provide the basis for future testing in patients with Sjögren’s. The study, “Stimulation of regulatory T…

A new study in mice suggests that metformin — a drug typically used to control blood sugar levels in diabetes — may be able to reduce inflammation and damage to the salivary glands in Sjögren’s syndrome. The study, “Metformin improves salivary gland inflammation and hypofunction in…

Aspirin-triggered resolvin D1 (AT-RvD1), a molecule that reduces tissue inflammation and promotes wound healing, restores the function of salivary glands and decreases the levels of immune T-helper 17 cells in a mouse model of  Sjögren’s syndrome, a study reports. The findings of the study, “Aspirin Triggered Resolvin…