Telitacicept (RC18), an experimental therapy being developed by RemeGen, significantly eased disease activity in people with primary Sjögren’s syndrome in a Phase 2 clinical trial, the company announced. “We are very excited to see the positive results from the Phase II clinical trial of telitacicept,” Jianmin Fang,…

Sensitivity to smell is reduced in people with Sjögren’s syndrome, compared with healthy controls, and appears to be linked to the severity of the disease, a new study reports. The study, “Olfactory impairment in patients with primary Sjogren’s syndrome and its correlation with organ involvement and immunological abnormalities,”…

A subset of immune cells, called CD4+CD8+ T-cells, is increased in the blood of patients with Sjögren’s syndrome, and their levels seem to correlate with lower disease activity, according to a small study. The findings suggest doctors could make use of those cells to track or even control how…

Infections with the Epstein-Barr virus (EBV), the most common member of the herpes virus family, may contribute to the development of Sjögren’s syndrome by increasing the proportion of immune cells with autoimmune functions, a recent study suggests. Therapies targeting the interaction between EBV and activated…

A combination of leflunomide and hydroxychloroquine significantly reduced disease activity, increased salivary flow, and improved patient-perceived health in patients with primary Sjögren’s syndrome, a pilot trial showed. Findings of the trial were revealed at the recent American College of Rheumatology 2018 Meeting, in Chicago. Timothy Radstake, MD, PhD, from the …

Decreased levels of memory B-cells, a kind of white blood cell, may help diagnose patients with primary Sjögren’s syndrome and determine the severity of their disease, a new study shows. Tests based on memory B-cell levels potentially could be used as disease markers for predicting outcomes and tracking the effect…

Musculoskeletal ultrasound is better than clinical examination and blood tests for the best management of  hand arthritis in Sjogren’s syndrome patients, according to a new study. The findings were presented recently at the European Lupus Meeting 2018, in Düsseldorf, Germany, in an abstract titled “PS6:120 Hand ultrasound guided therapeutic decisions…