Certain immune cell types found dysregulated in primary Sjögren’s

Certain immune cell types are dysregulated in people with primary Sjögren’s disease, according to a new study from researchers in China that points to the resulting alterations as possible drivers of the condition and factors influencing its severity. “Our study demonstrates significant alterations in circulating immune cell populations in…

Myeloid Cells Increase Inflammation, Worsen Sjögren’s Symptoms and Prognosis, Study Suggests

A type of immunosuppressive cells called myeloid-derived suppressor cells (MDSCs), high levels of which were found in patients with Sjögren’s syndrome, seem to worsen the symptoms and prognosis of the disease, a study reports. While the results seem counterintuitive, researchers found that MDSCs act on other regulatory immune cells, reducing their number…