A mutation in the TNIP1 gene resulted in a chronic autoimmune disease for two people, one of whom had symptoms similar to Sjögren’s disease, a study shows. The other patient had symptoms of systemic lupus erythematosus (SLE), another type of autoimmune disease. Experiments in mice with the mutation,…
Women with primary Sjögren’s syndrome are more likely to give birth prematurely and have babies born with congenital heart block (CHB) — a condition that disrupts the transmission of electrical signals within the heart needed to maintain a normal heartbeat — than women with other autoimmune conditions, a study…
Changes in the metabolic activity of certain immune cells may help to drive the inflammatory attacks that cause Sjögren’s syndrome, a recent study reported. According to its researchers, these findings suggest that targeting a specific metabolic pathway in immune cells, called aerobic glycolysis, may help to reduce disease activity…
The proteins CTSS and GSTO1 could accurately distinguish people with primary Sjögren’s syndrome from unaffected individuals, a study suggests, meaning they show promise as diagnostic biomarkers and possible therapeutic targets for Sjögren’s. “These insights may lead to the development of targeted therapies and improved management strategies for individuals living…
Lip salivary gland biopsy may not be predictive of a Sjögren’s syndrome diagnosis, particularly when it’s based on tissue samples classified as showing a low level of inflammation and damage, according to a study. In 16% of the cases assessed in the study, different pathology teams would draw different conclusions…
Kiniksa Pharmaceuticals has launched a Phase 2b clinical trial to test its injectable therapy abiprubart against a placebo in people with Sjögren’s syndrome. The trial, mainly designed to assess the treatment’s effects on disease severity, is expected to involve about 201 Sjögren’s patients. Kiniksa reports that the trial…
World Sjögren’s Day is held every July 23, the birthday of Henrik Sjögren, the Swedish ophthalmologist who first identified Sjögren’s syndrome in 1933, and this year, to observe the 40th anniversary of the Sjögren’s Foundation, Amgen has pledged a dollar-to-dollar match up to $40,000, meaning donations supporting…
A new photo-detection method was able to accurately and quantitatively measure lactoferrin levels in the tears of people with dry eye disease (DED) associated with Sjögren’s syndrome or other conditions, a study shows. The method also let researchers distinguish patients with DED caused by Sjögren’s from other DED…
The oral microbiome — the community of bacteria living in the mouth — of people with primary Sjögren’s syndrome (pSS) includes a large number of bacteria linked to inflammation and dental caries, or cavities, as well as bacteria that facilitate the colonization of the oral mucosa by other disease-causing…
Introducing immunosuppressive or biological therapies early in people with Sjögren’s syndrome may prevent its progression to a bodywide systemic condition, a study in France suggests. “In our study, we can see that the introduction of [immunosuppressive agents] or biotherapy in systemic forms is only effective in around 50% of…
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