A web-based tool to assess daily symptoms of Sjögren’s disease is easy to implement, was well accepted, and effectively captures the high day-to-day symptom variability among patients, a three-month pilot study shows. Data collected with the web app PEPSS over a pre-specified period differed from that captured with standard,…
KB-7898, Kronos Bio’s investigational therapy for Sjögren’s disease, was shown to lower antibody production and the release of inflammatory molecules in lab studies involving cell and animal models of autoimmune conditions, the company announced. Kronos is planning further preclinical studies to assess KB-7898’s safety and pharmacological properties…
An imaging test that measures damage to salivary glands may effectively be used, together with the presence of self-reactive antibodies, to diagnose Sjögren’s disease and determine disease staging. That’s according to a new study from China that investigated the use of the imaging test, called parotid sialography, alongside one…
Note: This story was updated Oct. 1, 2024, to clarify that Sjögren’s is a systemic disease, meaning it can affect moisture-producing glands, as well as other parts of the body. Ainos is planning to launch a Phase 3 clinical trial in Taiwan before the year’s end to evaluate the…
Topical application of the experimental therapy RCI001 prevented dry eye damage and improved tear secretion in a mouse model of Sjögren’s disease, according to a new study. Treatment in the mice also reduced markers of inflammation and oxidative stress, a type of cellular damage implicated in eye surface inflammation…
Dental implants for women with primary Sjögren’s disease — who commonly experience problems with their teeth due to dry mouth — appear to work well and improve quality of life over five years, with gum health and appearance similar to women without the disease, a new study found. According to…
Lip salivary gland biopsy using an auxiliary device called chalazion forceps may diagnose primary Sjögren’s disease as accurately as the conventional method, but with fewer procedure-related complications, a study suggests. Researchers noted that, compared with the conventional method, “the modified [lip salivary gland biopsy] … offers a good safety…
A mutation in the TNIP1 gene resulted in a chronic autoimmune disease for two people, one of whom had symptoms similar to Sjögren’s disease, a study shows. The other patient had symptoms of systemic lupus erythematosus (SLE), another type of autoimmune disease. Experiments in mice with the mutation,…
Women with primary Sjögren’s syndrome are more likely to give birth prematurely and have babies born with congenital heart block (CHB) — a condition that disrupts the transmission of electrical signals within the heart needed to maintain a normal heartbeat — than women with other autoimmune conditions, a study…
Changes in the metabolic activity of certain immune cells may help to drive the inflammatory attacks that cause Sjögren’s syndrome, a recent study reported. According to its researchers, these findings suggest that targeting a specific metabolic pathway in immune cells, called aerobic glycolysis, may help to reduce disease activity…
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