Primary Sjögren’s disease-associated interstitial lung disease (pSjD-ILD) — a form of Sjögren’s disease that’s characterized by scarring in the lungs — tends to lead to worse outcomes in biological males than in females, a new study reports. “Our retrospective study revealed that in patients with pSjD-ILD, male individuals were…
Immune B-cells that contain the receptor protein CD226 may play a role in the development and clinical manifestations of primary Sjögren’s disease, making CD226 a possible target for future treatments, a study reports. Data indicated that people with Sjögren’s had proportionally more CD226-positive B-cells in their bloodstream than their…
A traditional Chinese medicine formulation called Qihuang Jianpi ZiShen Granule (QJZG) may help to alleviate Sjögren’s disease by reducing inflammatory molecules and associated tissue damage, according to computer simulations and tests in a cell model of the disease. “This study provides evidence supporting the use of Chinese medicine…
Renaming Sjögren’s syndrome as Sjögren’s disease is meant to better reflect that it’s a serious autoimmune disease, not just a collection of symptoms, and to offer some clarity across clinical and research settings. An international group of doctors and patients agreed to the name change in 2023 through a…
Telitacicept safely and effectively eased disease activity in adults with primary Sjögren’s disease, according to data from a now-complete Phase 3 clinical trial conducted in China. Because the trial met its primary goal, developer Remegen plans to ask China’s regulator, the Center for Drug Evaluation of the National Medical…
Novartis’ investigational antibody therapy ianalumab (VAY736) safely and effectively eases disease activity in adults with Sjögren’s disease, topline results from a pair of Phase 3 clinical trials show. According to the therapy’s developer, ianalumab has the potential to become the first targeted treatment to be approved for people…
Levels of the receptor protein Mer tyrosine kinase (MerTK) in small salivary glands may be a useful marker for tracking disease activity and estimating tissue damage in Sjögren’s disease, a study reports. Researchers found that elevated MerTK, which plays a role in immune inflammation, was significantly associated with more…
Prompt treatment for primary Sjögren’s disease in patients who develop ischemic stroke, where parts of the brain die due to the lack of blood flow, helps to promote neurological recovery and reduce the risk of stroke recurrence, a single-center study in China found. In fact, the researchers reported that…
The Sjögren’s Foundation is asking people to make a pledge to take action for World Sjögren’s Day on July 23 to help support the foundation’s research and education programs. Longtime Sjögren’s Foundation supporter Debby Vivari will donate $2 for the first 5,000 pledges and anyone can make a pledge…
Anti-SSB antibodies may be a predictor of decreased lung function in people with primary Sjögren’s disease who also have interstitial lung disease (ILD), a group of conditions marked by inflammation and scarring in the lungs, according to a retrospective study from Romania. Particularly, the presence of these autoantibodies was…
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