People with primary Sjögren’s disease diagnosed at a younger age and who harbor certain self-reactive antibodies are more likely to have kidney involvement, a study in South Korea suggests. While most with kidney involvement were asymptomatic, about a third had impaired kidney function when they were diagnosed and 25%…
About 2 in 3 women and men with Sjögren’s disease experience challenges in their sexual lives that go beyond physical symptoms, such as vaginal dryness or difficulty getting and keeping an erection, and these may include stress, social taboos, and poor body image, a study finds. Physical and emotional…
More than half of women with Sjögren’s disease show loss of bone tissue, or bone erosion, according to a study carried out in Brazil. Findings also showed the volume of bone erosion increased by 7% per year, and was 3.5 times higher for women who had gone through menopause.
A woman with Sjögren’s disease was the first to receive an experimental cell therapy for xerostomia, or severe dry mouth, in a clinical trial at the University of Wisconsin (UW). As part of the Phase 1 study (NCT06392711), six patients are receiving one injection of their own mesenchymal…
A rare condition called cerebral venous thrombosis or CVT, characterized by blood clots forming in veins in the brain, can occur in people with primary Sjögren’s disease, a new study reports. The findings suggest that Sjögren’s patients with co-occurring CVT don’t always show well-known Sjögren’s symptoms, such as dry…
People with Sjögren’s disease who are positive for self-reactive, anti-SSA antibodies may develop more severe dry eye symptoms than those without anti-SSA and anti-SSB antibodies. That’s according to a study carried out in Mexico that also found patients with anti-SSA antibodies had significantly more signs of eye dryness associated…
People with psoriasis, an autoimmune disorder marked by itchy, red patches of skin, appear to have a 50% increased risk of developing Sjögren’s syndrome, according to an analysis of medical records involving nearly 600,000 people. The risk of developing Sjögren’s was even higher…
Treatment with Evoxac (cevimeline hydrochloride) significantly improved salivary flow and eased symptoms of dry mouth in people with Sjögren’s syndrome, according to a meta-analysis of three clinical trials. These findings suggest that Evoxac, an approved Sjögren’s treatment, is a “promising therapeutic option, particularly for individuals with mild to moderate…
Problems with regulatory T-cells, or Tregs — a type of immune cell that plays a key role in dampening the body’s immune responses — drives the development of Sjögren’s disease, according to a recent mouse study. Treg dysfunction, also demonstrated by the genetic signatures in immune cells isolated from…
People with primary Sjögren’s disease and neuropathic pain — pain caused by damage or dysfunction of the nervous system — are more likely to experience lower urinary tract problems than those without neuropathic pain. That’s according to a study in Turkey, which also found that neuropathic pain appeared to…
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