News

People with Sjögren’s disease are at higher risk of developing non-Hodgkin lymphoma (NHL), a type of blood cancer, as well as other malignancies, a study reports. Researchers also identified several risk factors associated with cancer development in Sjögren’s patients, noting that nearly a quarter of deaths seen among…

Using stem cell eye drops — ones containing mesenchymal stem cells, or MSCs, which can give rise to other cell types — was shown to ease the signs and symptoms of refractory, or hard-to-treat, dry eye disease in adults with and without Sjögren’s disease, according to new data from…

Cullinan Therapeutics is planning the launch of a clinical trial in the U.S. to test its treatment candidate CLN-978 in people with Sjögren’s disease. The study will be open to Sjögren’s patients whose disease is active and moderate to severe, and who are positive for anti-SSA/Ro antibodies and/or…

Immunovant is planning to launch a potentially registrational clinical trial this summer to test its treatment candidate IMVT-1402 in people with Sjögren’s disease. The company said that its investigational new drug application — a formal request to the U.S. Food and Drug Administration (FDA) seeking permission to start…

Men with Sjögren’s disease show more early signs of lung and heart dysfunction than women and may be at an increased risk of developing pulmonary hypertension, a cardiovascular complication of Sjögren’s, a study reports. “As male patients demonstrated a greater predisposition to developing [pulmonary hypertension] … regular echocardiographic…

A naturally occurring molecule that has the ability to regulate gene activity may represent a promising therapeutic target for Sjögren’s disease and other autoimmune conditions, according to a study. Mimicking the activity of the molecule, miR-216a-3p, eased inflammation and scarring in a rat model of the disease. Its therapeutic…

More severe salivary gland damage and lymph node enlargement detected by ultrasound examination are associated with higher disease activity in primary Sjögren’s disease, a study in South Korea reports. Also, researchers found that more severe salivary gland damage was tied to a higher prevalence of laboratory risk factors for…

April is Sjögren’s Awareness Month, and a U.S.-based nonprofit is gearing up to help the community spread the word about Sjögren’s disease — and the many ways people impacted by this autoimmune condition can get involved. For this year’s awareness month, the Sjögren’s Foundation is inviting supporters…

Nipocalimab, an experimental antibody-based therapy being developed by Johnson & Johnson, was granted fast track status by the U.S. Food and Drug Administration (FDA) for adults with moderate to severe Sjögren’s disease. Fast track status is given to candidate therapies for serious health conditions with the…

Nearly 80% of women with Sjögren’s disease experience sexual dysfunction, with common symptoms including vaginal dryness, lower sexual satisfaction, and difficulty with arousal, a Chinese study finds. The findings highlight the need of “increased awareness and recognition of sexual health in clinical practice,” the researchers wrote, adding that “policymakers…