News

Blood levels of two self-targeting antibodies commonly elevated in people with Sjögren’s disease may define distinct patient groups with different levels of disease severity and organ involvement, a single-center study in China shows. For example, testing positive for anti-Ro52 antibodies alone was associated with lung disease, while testing positive…

The first patient has been dosed in a newly launched global clinical trial evaluating the safety and effectiveness of telitacicept, given as subcutaneous, or under-the-skin, injections, in adults with primary Sjögren’s disease. The Phase 3 study, dubbed UPSTREAM SjD (NCT07404865), will test the therapy, in an estimated 250…

Sjögren’s Awareness Month is marked each year in April, and for this year, advocates and organizations are encouraging people affected by Sjögren’s disease to continue spreading awareness by sharing their personal stories and participating in events across the U.S. Leading the charge is the Sjögren’s Foundation, a Virginia-based nonprofit.

Trinity Biotech, which specializes in diagnostic test kits, is partnering with the University at Buffalo, New York (UB) to develop and commercialize new testing strategies to improve the detection of Sjögren’s disease and aid in its diagnosis. “Sjögren’s is a significantly underdiagnosed condition that imposes a major burden…

People with primary Sjögren’s disease, particularly those with more severe illness, show significantly different patterns of alternative splicing — a process in which cells mix and match gene instructions to create different versions of a protein — in 10 genes compared with healthy people, according to a study in China.

Initial data from an early clinical trial testing CLN-978, Cullinan Therapeutics’ experimental therapy, in adults with moderate to severe Sjögren’s disease are expected in the final months of the year. The announcement was part of a company press release providing the latest financial results and corporate updates.

Adults with primary Sjögren’s disease are at a higher risk of developing colorectal and pancreatic cancers — especially women and older patients — according to a Korean study. “Further research should explore the underlying mechanisms and the impact of [primary Sjögren’s disease] duration and severity on cancer risk,” researchers…

People living with Sjögren’s disease often experience disabling symptoms that have a substantial impact on day-to-day life, even as they face dismissal from healthcare providers and judgment from peers, a new review study reports. Based on the findings, scientists are calling for greater efforts to support people with Sjögren’s,…

The “Sjögren’s protein score,” a newly identified blood protein signature of Sjögren’s disease, may help doctors measure inflammation inside the salivary glands without the need for a biopsy, a new study suggests. Results from the blood test, based on a group of 16 immune-related proteins, reflected local glandular…

A computer-based gene activity analysis combined with artificial intelligence (AI) methods has identified a dozen potential biomarkers that may ultimately help clinicians in reaching a Sjögren’s disease diagnosis more quickly, according to researchers in China. Their study found that activity levels of these new biomarkers were significantly associated with…