News

Novartis’ investigational antibody therapy ianalumab (VAY736) safely and effectively eases disease activity in adults with Sjögren’s disease, topline results from a pair of Phase 3 clinical trials show. According to the therapy’s developer, ianalumab has the potential to become the first targeted treatment to be approved for people…

Levels of the receptor protein Mer tyrosine kinase (MerTK) in small salivary glands may be a useful marker for tracking disease activity and estimating tissue damage in Sjögren’s disease, a study reports. Researchers found that elevated MerTK, which plays a role in immune inflammation, was significantly associated with more…

Prompt treatment for primary Sjögren’s disease in patients who develop ischemic stroke, where parts of the brain die due to the lack of blood flow, helps to promote neurological recovery and reduce the risk of stroke recurrence, a single-center study in China found. In fact, the researchers reported that…

The Sjögren’s Foundation is asking people to make a pledge to take action for World Sjögren’s Day on July 23 to help support the foundation’s research and education programs. Longtime Sjögren’s Foundation supporter Debby Vivari will donate $2 for the first 5,000 pledges and anyone can make a pledge…

Anti-SSB antibodies may be a predictor of decreased lung function in people with primary Sjögren’s disease who also have interstitial lung disease (ILD), a group of conditions marked by inflammation and scarring in the lungs, according to a retrospective study from Romania. Particularly, the presence of these autoantibodies was…

Certain immune cell types are dysregulated in people with primary Sjögren’s disease, according to a new study from researchers in China that points to the resulting alterations as possible drivers of the condition and factors influencing its severity. “Our study demonstrates significant alterations in circulating immune cell populations in…

Using artificial intelligence (AI) to analyze biopsies of the salivary glands in people with Sjögren’s disease may help identify patients who are likely to have disease involvement in vital organs, a new study reports. According to the researchers, the novel model developed by the team “achieves high accuracy in…

People with Sjögren’s disease tend to have poor oral health relative to the general population, despite generally good hygiene practices, a study found. Sjögren’s was associated with tooth decay, cavities, and wear, ultimately requiring more procedures to restore teeth. Hyposalivation, a common Sjögren’s disease symptom in which the…

Efgartigimod is entering a Phase 3 clinical trial after data from a proof-of-concept Phase 2 trial showed it outperformed a placebo at easing symptoms and signs of primary Sjögren’s disease, the treatment’s developer said. Argenx shared the data at the European Congress of Rheumatology (EULAR) 2025, held June…

Newborns of mothers with primary Sjögren’s disease may be at a higher risk of developing heart conditions. That’s according to a study in China, which also found this increased risk was significantly associated with higher maternal disease activity. “Maternal [primary Sjögren’s], especially with high disease activity, elevates the risk…