News

People with Sjögren’s disease, especially younger patients, have more infections and more repeat infections than their healthy peers, according to a study that analyzed medical records. Most infections were recorded after a Sjögren’s diagnosis, which “may reflect immunologic shifts associated with the onset of SjD [Sjögren’s disease], utilization…

Blood levels of several molecules involved in promoting or dampening inflammation may help distinguish people with Sjögren’s disease from healthy individuals and offer clues about disease activity and gland involvement, according to a small study. People with Sjögren’s showed significantly higher blood levels of the pro-inflammatory molecules IL-15, MCP-1,…

About five out of every 100 people with Sjögren’s disease may experience serious cardiovascular events over nearly 10 years of follow-up, and these events are linked to a higher risk of death of any cause, a study in Spain shows. In addition to traditional cardiovascular risk factors, disease-specific factors…

More than half of people with Sjögren’s disease have high levels of an inflammatory protein called interferon-alpha (IFN-alpha) and a distinct pattern of immune system dysregulation, according to data from people living in the U.K. Study findings suggest that IFN-alpha may be a critical marker to distinguish between different…

People around the world are gearing up to observe World Sjögren’s Day, an annual campaign dedicated to raising awareness and understanding of Sjögren’s disease, a chronic autoimmune disorder that affects millions of people worldwide. Created by the Sjögren’s Foundation in 2005, World Sjögren’s Day is observed each year on…

Innovent Biologics, a China-based biopharmaceutical company, is planning to launch a Phase 2 clinical trial testing its experimental therapy IBI355 in people with Sjögren’s disease. The study will be conducted in China and is expected to launch in early 2027, according to a press release from Innovent…

Intermittent fasting may offer a new way to ease the dry eye symptoms that commonly affect people with Sjögren’s disease, according to a new study in mice. The alternating fasting and eating regimen was found to restore a healthier gut environment in the animals. This shift ultimately reduced immune…

Among people with Sjögren’s disease, those diagnosed before age 45 may face an increased risk of unusually high antibody levels in the blood and chronic lung disease, according to a study of more than 5,000 patients in China. Researchers linked these features to a distinct pattern of immune cells…

A self-perpetuating loop where T-cells and B-cells continuously activate each other may contribute to the development of Sjögren’s disease, according to a cell-based study that uncovers a potential new target for selective therapies. Led by scientists at Keio University School of Medicine, in Tokyo, Japan, a research team analyzed…

Efgartigimod, a treatment approved for certain autoimmune diseases, was linked to maintained clinical responses and low disease activity scores for up to 72 weeks in people with Sjögren’s disease, according to data from a small Phase 2 clinical trial and its open-label extension study. Participants who showed a clinical…