Treatment with Evoxac (cevimeline hydrochloride) significantly improved salivary flow and eased symptoms of dry mouth in people with Sjögren’s syndrome, according to a meta-analysis of three clinical trials. These findings suggest that Evoxac, an approved Sjögren’s treatment, is a “promising therapeutic option, particularly for individuals with mild to moderate…
Problems with regulatory T-cells, or Tregs — a type of immune cell that plays a key role in dampening the body’s immune responses — drives the development of Sjögren’s disease, according to a recent mouse study. Treg dysfunction, also demonstrated by the genetic signatures in immune cells isolated from…
People with primary Sjögren’s disease and neuropathic pain — pain caused by damage or dysfunction of the nervous system — are more likely to experience lower urinary tract problems than those without neuropathic pain. That’s according to a study in Turkey, which also found that neuropathic pain appeared to…
Ainos is partnering with Taiwan Tanabe Seiyaku, a subsidiary of Mitsubishi Tanabe Pharma, to advance the manufacturing and promotion of its investigational low-dose formulation of interferon alpha for Sjögren’s disease in Taiwan. Both parties will clarify the details of the partnership in a formal agreement. According to Ainos,…
Drinking a traditional Chinese medicinal tea led to improvements in tear production, reductions in ocular dryness, and better sleep quality in patients with Sjögren’s disease, a study shows. Sjögren’s patients also reported a significant reduction in using artificial tears, from a…
Johnson & Johnson’s antibody-based therapy candidate nipocalimab has been granted breakthrough therapy designation by the U.S. Food and Drug Administration (FDA) for treating adults with moderate to severe Sjögren’s disease. This status is meant to accelerate the development and regulatory review of investigational therapies intended to treat serious…
Blood levels of antibodies against aquaporin 5 (anti-AQP5) — a protein that regulates water movement in tissues — may be used as a biomarker to diagnose primary Sjögren’s disease, a study…
Blood levels of transthyretin (TTR) may be used as a biomarker to predict and monitor disease activity in people with primary Sjögren’s disease, a study in China suggests. TTR is a protein that transports thyroxine, the main hormone secreted by the thyroid gland, to the liver and brain. It’s…
A web-based tool to assess daily symptoms of Sjögren’s disease is easy to implement, was well accepted, and effectively captures the high day-to-day symptom variability among patients, a three-month pilot study shows. Data collected with the web app PEPSS over a pre-specified period differed from that captured with standard,…
KB-7898, Kronos Bio’s investigational therapy for Sjögren’s disease, was shown to lower antibody production and the release of inflammatory molecules in lab studies involving cell and animal models of autoimmune conditions, the company announced. Kronos is planning further preclinical studies to assess KB-7898’s safety and pharmacological properties…
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