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A panel of four blood markers may help identify people with Sjögren’s disease, even those who lack common disease-associated antibodies, a new study finds. Researchers also identified blood marker panels linked to overall disease activity and involvement of specific organs. Although more studies are needed to confirm the results,…

A Florida man is preparing to pilot a stand-up paddleboard 540 miles along the state’s Intracoastal Waterway to raise awareness and research funds for Sjögren’s disease, a chronic autoimmune condition his daughter was diagnosed with at age 11 after two years of painful symptoms and unanswered questions. Jason Parker,…

Argenx is stopping a global clinical trial testing its drug efgartigimod against a placebo in adults with moderate to severe Sjögren’s disease after an independent analysis deemed the study unlikely to meet its main goal. Based on a predefined interim analysis of the trial’s data, an independent data…

Add-on treatment with Artiva Biotherapeutics’ experimental cell therapy AlloNK (AB-101) was associated with improvements in symptoms and increased saliva flow at six months in a small group of adults with difficult-to-treat Sjögren’s disease in a basket clinical trial. However, the global Phase 2a study (NCT06991114) is a…

Amgen’s experimental therapy dazodalibep led to rapid, sustained reductions in disease activity among adults with moderate-to-severe Sjögren’s disease in a global clinical trial, according to top-line data announced by the company. “The results mark an important step forward for people living with Sjögren’s disease, a condition with significant…

Swelling of the major salivary glands without dry mouth at the time of a Sjögren’s disease diagnosis may point to a distinct disease profile marked by younger age, higher disease activity, and more severe glandular abnormalities, a study from South Korea suggested. “Recognition of this [Sjögren’s] presentation may support…

Four genes related to an immune signaling protein called interferon-gamma (IFN-gamma) are more active in people with Sjögren’s disease, and measuring their activity levels may help distinguish patients from healthy individuals, a study found. Further analysis pointed to macrophages — immune cells involved in inflammation, tissue repair, and IFN-gamma…

A global clinical trial testing the safety and early effectiveness of MRT-6160, an oral treatment for Sjögren’s disease, is now recruiting an estimated 344 adults with the autoimmune condition. The experimental therapy is designed to reduce the activity of two major types of immune cells that help drive Sjögren’s,…

Immunosuppressive treatment for Sjögren’s disease-associated interstitial lung disease (ILD) has become more common in recent years, particularly among patients with greater respiratory symptoms or poorer lung function, a European study found. Despite the shift toward more frequent and diverse treatment, the proportion of patients whose lung disease worsened after…

People diagnosed with Sjögren’s disease at an older age may have more clinically recognized problems with their lungs than younger patients, a study found. Due to incomplete data on potential influencing factors, further studies are needed to confirm these findings, researchers emphasized. The study, “Clinical, serological, and hematological…