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Stellular Bio has raised early-stage investment to advance its treatment candidate, STLR-201, into clinical testing as a potential off-the-shelf therapeutic option for dry eye caused by Sjögren’s disease. Part of a therapy class called platelet-derived regenerative biologics (PRBs), STLR-201 is derived from stem cells that can produce platelets,…

A new publicly available artificial intelligence (AI) tool that analyzes results from routine laboratory blood tests may improve the diagnosis of Sjögren’s disease, according to a multicenter study in China. The AI system, called Sjogren Multi-criterion Feature Integration Framework (SMFIF), distinguished people with Sjögren’s from those with Sjögren’s-like…

Ianalumab, an experimental treatment for Sjögren’s disease from Novartis, has been granted breakthrough therapy designation by the U.S. Food and Drug Administration (FDA). The FDA gives this designation to experimental therapies that have the potential to address unmet needs in the care of serious diseases, with the goal…

Primary Sjögren’s disease may be divided into two main clinical subtypes, according to a recent study that used artificial intelligence. “Our study suggests that primary Sjögren’s syndrome consists of distinct clinical subtypes with different organ involvement patterns and immunological features,” the researchers wrote. “The data-driven classification system complements traditional…

A molecule that helps control how genes work, called hsa-miR-661, may help doctors diagnose primary Sjögren’s disease and could one day become a treatment target, according to a study from China. Researchers found that levels of hsa-miR-661 were significantly higher in circulating immune cells taken from people with primary…

Childhood-onset Sjögren’s disease can cause lasting damage to the body’s organs by early adulthood, regardless of how active the disease has been or how severely the symptoms have manifested. Those are the findings of a single-center study in the U.K. that investigated the “long-term disease trajectories and complications of…

Note: This story was updated Dec. 17, 2025, to correct that the infiltrations were done in the parotid glands, not the parathyroid. A minimally invasive treatment that involves irrigating the major salivary glands with corticosteroids, a type of anti-inflammatory medication, significantly reduced both objective and subjective measures of dry mouth…

Four genes involved in a form of cell death called pyroptosis are highly active in people with Sjögren’s disease and may serve as disease biomarkers or therapeutic targets, a study reports. By examining the activity of each of the genes — PECAM1, IFI16, AIM2, and MPEG1 —the researchers…

A new artificial intelligence (AI) tool has demonstrated the ability to significantly enhance the diagnosis of Sjögren’s disease by rapidly and accurately analyzing tissue samples, according to a multicenter European study. The AI system achieved an accuracy of more than 87% in classifying the focus score, which is the…

The severity of fatigue experienced by people with Sjögren’s disease affects their pain severity, and also has an impact on the effect of external factors, such as weather changes and loud noises, that can amplify a patient’s pain. That’s according to the findings of a single-center study in Italy,…