A machine learning tool that can analyze certain molecules in stool samples may help to better diagnose primary Sjögren’s disease, according to a new study from researchers in China. The team found that their novel model, using fecal samples, could distinguish primary Sjögren’s patients from healthy individuals with an…
Women with primary Sjögren’s disease often face a combination of problems — key among them a weaker sense of taste and smell, disrupted sleep, and sexual discomfort caused by dryness — that reduce their quality of life. That’s according to a new review of more than a dozen studies,…
Rise Therapeutics plans to launch a Phase 1 clinical trial testing R-2487, its experimental oral therapy for autoimmune diseases, in people with Sjögren’s disease. R-2487, which leverages bacterial proteins to suppress the abnormal immune responses in autoimmune diseases like Sjögren’s, “is disease-modifying, focusing on long-term immune correction rather…
Primary Sjögren’s disease-associated interstitial lung disease (pSjD-ILD) — a form of Sjögren’s disease that’s characterized by scarring in the lungs — tends to lead to worse outcomes in biological males than in females, a new study reports. “Our retrospective study revealed that in patients with pSjD-ILD, male individuals were…
Immune B-cells that contain the receptor protein CD226 may play a role in the development and clinical manifestations of primary Sjögren’s disease, making CD226 a possible target for future treatments, a study reports. Data indicated that people with Sjögren’s had proportionally more CD226-positive B-cells in their bloodstream than their…
A traditional Chinese medicine formulation called Qihuang Jianpi ZiShen Granule (QJZG) may help to alleviate Sjögren’s disease by reducing inflammatory molecules and associated tissue damage, according to computer simulations and tests in a cell model of the disease. “This study provides evidence supporting the use of Chinese medicine…
Renaming Sjögren’s syndrome as Sjögren’s disease is meant to better reflect that it’s a serious autoimmune disease, not just a collection of symptoms, and to offer some clarity across clinical and research settings. An international group of doctors and patients agreed to the name change in 2023 through a…
Telitacicept safely and effectively eased disease activity in adults with primary Sjögren’s disease, according to data from a now-complete Phase 3 clinical trial conducted in China. Because the trial met its primary goal, developer Remegen plans to ask China’s regulator, the Center for Drug Evaluation of the National Medical…
Novartis’ investigational antibody therapy ianalumab (VAY736) safely and effectively eases disease activity in adults with Sjögren’s disease, topline results from a pair of Phase 3 clinical trials show. According to the therapy’s developer, ianalumab has the potential to become the first targeted treatment to be approved for people…
Levels of the receptor protein Mer tyrosine kinase (MerTK) in small salivary glands may be a useful marker for tracking disease activity and estimating tissue damage in Sjögren’s disease, a study reports. Researchers found that elevated MerTK, which plays a role in immune inflammation, was significantly associated with more…
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