Margarida Maia, PhD,  science writer—

A woman with Sjögren’s disease was the first to receive an experimental cell therapy for xerostomia, or severe dry mouth, in a clinical trial at the University of Wisconsin (UW). As part of the Phase 1 study (NCT06392711), six patients are receiving one injection of their own mesenchymal…

Dental implants for women with primary Sjögren’s disease — who commonly experience problems with their teeth due to dry mouth — appear to work well and improve quality of life over five years, with gum health and appearance similar to women without the disease, a new study found. According to…

In adults with Sjögren’s syndrome with missing teeth, implant-supported overdentures — which are removable dentures that rest on implants — may improve the ability to chew, potentially leading to better quality of life, a study has found. The study, “Implant supported overdentures in Sjögren’s disease patients: a multicentre…

Autologous serum and platelet-rich eye drops work equally well to relieve dry eyes in people with primary Sjögren’s syndrome, but the latter may be more convenient because they take less time to prepare, a study suggests. The study, “Efficacy and safety of platelet-rich plasma and autologous-serum eye drops…

People with Sjögren’s syndrome who’ve had it for fewer than three years or whose disease is more active are at a higher risk of developing lupus, according to a study in Korea. Other factors linked to a higher lupus risk included a low number of white blood cells,…

Dazodalibep, Horizon Therapeutics’ experimental therapy for Sjögren’s syndrome, was found to safely and effectively ease disease activity and symptoms across two divergent groups of people with the chronic autoimmune disorder. These groups included people with Sjögren’s who had generally been excluded from recent clinical trials — patients with…

People with peripheral neuropathy co-occurring with primary Sjögren’s syndrome may see their symptoms ease or even disappear with immunosuppressive therapy, a study found. Researchers observed that Sjögren’s patients who tested positive for certain self-reactive antibodies or had too high levels of proteins called globulins in the blood were at…

People who have a parent or sibling with an autoimmune disease are nearly six times as likely to develop primary Sjögren’s syndrome (pSS) than those who have no immediate family with such health issues, a meta-analysis study has found. Other risk factors for pSS include a history of pregnancy,…

Sugar metabolism — all chemical reactions involved in making or breaking down glucose, or blood sugar — is overly active in B-cells, a type of immune cell implicated in Sjögren’s syndrome, and may provide a target for developing treatments, a study suggests. The study, “mTORC1-GLUT1-mediated glucose metabolism drives…

Cytotoxic CD8+ T-cells, a type of immune cells, build up in the salivary glands of the lips of patients with severe Sjögren’s syndrome, where they may kill the epithelial cells that line the glands, according to a new study. As these cells die, the glands no longer can produce…