Joana Carvalho, PhD, managing science editor —

Most patients with primary Sjögren’s syndrome experience gastrointestinal problems but have no recommended treatments available due to lack of information about the underlying causes, a pilot study reports. Future studies will be needed to identify these causes and to explore the possible relationship between these symptoms and other conditions,…

Luminary Therapeutics will collaborate with researchers at Case Western Reserve University to develop a new form of CAR T-cell therapy that uses the B-cell activating factor (BAFF) target as a treatment for Sjogren’s syndrome and mantle cell lymphoma. The…

Researchers have discovered the mechanisms by which Bcl-6 — a protein that is considered a “master regulator” of the immune system — controls the activity of a subset of immune T-cells involved in a range of disorders. According to researchers, knowledge of these mechanisms may prompt the development of…

Routine examinations of patients with primary Sjögren’s syndrome should include cognitive function tests to assess the presence of impairments, a review study recommends. The study, “Cognitive Function in Primary Sjögren’s Syndrome: A Systematic Review,” was published in Brain Sciences. Sjögren’s syndrome is a chronic autoimmune disease characterized…

People with Sjögren’s syndrome have significant alterations in the composition of gut bacteria compared to healthy individuals, some of which seem to be directly associated with eye dryness, one of the hallmarks of the disorder, according to a study. The findings of the study, “Gut microbial dysbiosis in…

Aspirin-triggered resolvin D1 (AT-RvD1), a molecule that reduces tissue inflammation and promotes wound healing, restores the function of salivary glands and decreases the levels of immune T-helper 17 cells in a mouse model of  Sjögren’s syndrome, a study reports. The findings of the study, “Aspirin Triggered Resolvin…

Sjögren’s syndrome patients are more likely to experience both aortic aneurysms and aortic dissection — two medical complications that affect the wall of the aorta, the largest blood vessel in the body that carries blood from the heart to the rest of the body. The study with that finding,…

Larger differences in the size and volume of red blood cells — measured with a blood parameter called red blood cell distribution width — are linked to poor prognosis and survival in patients with primary Sjogren’s syndrome affected by pulmonary arterial hypertension (PAH), researchers found. Their study, “Red blood…

Patients with primary Sjögren’s syndrome (PSS) have stiffer arteries and more atherosclerotic plaques than control subjects without the disease, a study found. The findings suggest that PSS patients have a higher risk of cardiovascular diseases. The study, “Association between primary Sjogren’s syndrome, arterial stiffness, and subclinical atherosclerosis: a systematic review…

A type of immunosuppressive cells called myeloid-derived suppressor cells (MDSCs), high levels of which were found in patients with Sjögren’s syndrome, seem to worsen the symptoms and prognosis of the disease, a study reports. While the results seem counterintuitive, researchers found that MDSCs act on other regulatory immune cells, reducing their number…