A Chinese herbal medication called SS-1 can reduce inflammation and improve saliva flow, likely due to an inhibitory effect on dendritic cells — a component of the innate immune system, according to a recent study in a mouse model of Sjögren’s syndrome. The study, “Effect of…
People with early-onset primary Sjögren’s syndrome may need more intensive glucocorticoid and immunosuppressant therapy, closer follow-up, and regular monitoring than is customary, due to greater immune system activation and a less favorable prognosis than patients with later-onset disease, a study suggests. The study, “Patients with early-onset primary…
The amount of a protein called ATG5 in tears may pinpoint people whose dry eye symptoms are related to Sjögren’s syndrome with greater accuracy than standard diagnostic tests, a study has found. However, ATG5’s potential as a biomarker of the disorder should be investigated further, the researchers said. The…
Using the PI3K-delta inhibitor seletalisib as an add-on to standard treatment showed a trend toward easing disease activity and dryness, and significantly lowered patient-reported fatigue in people with primary Sjögren’s syndrome (pSS), according to data from a Phase 2 trial. Findings from this proof-of-concept study (NCT02610543) —…
Attention deficits may underlie the cognitive impairment that impacts a substantial portion of Sjögren’s syndrome patients with neurological symptoms, according to a new study. Such impairment is likely to affect other cognitive functions, as well as the ability to perform job-related tasks and engage in social activities, the researchers…
The University of Queensland’s technology transfer company, UniQuest, will partner with the biotechnology company CSL Limited to develop and commercialize the university’s antigen specific immune tolerance induction (ASITI) technology for the treatment of Sjogren’s syndrome. As an autoimmune disorder, Sjogren’s syndrome involves the immune system…
Get regular updates to your inbox.