Iscalimab, an investigational antibody therapy from Novartis, showed promise for safety and preliminary efficacy for lessening disease activity in people with primary Sjögren’s syndrome who experience symptoms across the body. Larger and longer studies are warranted to assess the clinically meaningful benefits of the potential therapy, researchers…
Many people with Sjögren’s syndrome experience oral symptoms beyond mouth dryness — with trouble in speaking, oral ulcers, and difficulty swallowing identified as the ones that most impact their quality of life and finances — a study based on a U.S. patient survey has found. The study was presented…
Orencia (abatacept), an immunotherapy used in rheumatic diseases, failed to reduce disease activity in patients with early active primary Sjögren’s syndrome after 24 weeks of treatment, results from the ASAPIII Phase 3 trial show. However, more patients reported an easing of disease symptoms while taking Orencia, compared…
Interstitial lung disease (ILD), or lung tissue scarring, commonly occurs in people with primary Sjögren’s syndrome in China and significantly burdens their quality of life, in particular their physical capacity, a Chinese study reports. Strengthening early interventions and treatment is of great importance in preventing ILD and improving…
Immunoglobulin injections may be a good choice to help resolve damage to the nerves that provide sensation or underly movement — a condition called peripheral neuropathy — in patients with Sjögren’s syndrome, a review…
New diagnostic criteria for systemic lupus erythematosus (SLE), released by the European and American rheumatology societies, helps to better distinguish patients with lupus from those with primary Sjögren’s syndrome, a study reports. The study, “New 2019 SLE EULAR/ACR classification criteria are valuable for distinguishing patients with SLE…
Immune regulatory B-cells (Bregs) are less abundant in patients with primary Sjögren’s syndrome, and are inversely correlated with disease activity, a study suggests. Therefore, low blood Bregs may help to discriminate between patients and healthy subjects, and assist doctors in diagnosis, especially when patients lack the classical…
Eye drops that contain a DNA-degrading enzyme are safe and potentially effective against eye damage and discomfort in people with dry eye disease, such as those who have Sjögren’s syndrome, early data from a Phase 1/2 trial show.
A supervised walking program, practiced three times a week for 16 weeks, safely improves cardiorespiratory fitness and exercise capacity while reducing fatigue in women with primary Sjögren’s syndrome, a clinical study found. The study, “Supervised walking improves cardiorespiratory…
Women with primary Sjögren’s syndrome (pSS) do not need to follow specific dietary guidelines to  maintain good nutrition and oral health, a Norwegian study suggests. Furthermore, the patients adequately follow the recommended dietary intakes, which do not seem to influence salivary secretion, the…
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