Signaling molecules secreted by stem cells in teeth have anti-inflammatory properties that could be useful for the treatment of Sjögren’s syndrome, recent research in mice shows. The findings were published in Stem Cell Research & Therapy, in the study, “Secreted factors from dental pulp stem cells…
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Women with primary Sjögren’s syndrome experience more negative stressful life events than healthy people in the year before symptom onset, and the number of these negative events is associated with more severe disease activity, a study has found. “These results suggest that we…
Oral treatment with a molecule produced by bacteria, called colonization factor antigen I, can reduce or halt the progression of Sjögren’s syndrome, a mouse study suggests. Researchers believe these findings provide the basis for future testing in patients with Sjögren’s. The study, “Stimulation of regulatory T…
A newly established cellular model of the tear gland may be useful for studying Sjögren’s syndrome and other diseases in which the tear glands become damaged, according to researchers. The model was described in a new study, “Exploring the human lacrimal gland using organoids and single-cell…
Most patients with Sjögren’s syndrome and other rheumatic diseases develop antiviral antibodies after their first COVID-19 vaccine shot, but their treatment affects the chances of them developing antibodies, a recent study has found. In particular, an antibody response was significantly less likely in patients receiving…
The Sjögren’s Foundation has developed clinical practice guidelines for healthcare providers to improve the diagnosis, evaluation, and care of Sjögren’s syndrome patients with lung manifestations. The guidelines, which include 52 recommendations for Sjögren’s evaluation and…
A variant of the LILRA3 gene may be associated with greater lymphoma susceptibility in a group of Sjögren’s syndrome patients with disease onset prior to age 40, a study reports. The variant could be a potential biomarker of…
In observance of Sjögren’s Awareness Month in April, the Sjögren’s Foundation is inviting individuals with to share their stories to help raise awareness about this complex condition. This year’s theme, “Coming Together to Conquer Sjögren’s,” will showcase the many Faces of Sjögren’s and illustrate…
People with primary Sjögren’s syndrome are six times more likely to be deficient in vitamin B12, a study found, supporting the need for screening and treating vitamin B12 deficiency in these patients. The study “Association of Primary Sjögren’s Syndrome and Vitamin B12 Deficiency: A…
Production of Myd88, a protein associated with autoimmune diseases, in distinct types of cells mediates different characteristics of primary Sjögren’s syndrome, a study in mouse models of this disease reported. These findings have implications for targeted therapies, as Myd88 activation may be protective in certain cell types and organs,…
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