News

Fatigue had the biggest impact on daily activities among people with primary Sjögren’s syndrome and was one of a number of symptoms associated with increased anxiety, depression, and physical limitations, according to a recent U.K. study. This effect was markedly reduced in patients with a longer disease duration, suggesting that…

Dry eye disease is more severe in people with primary Sjögren’s syndrome than in other patients, but their perception of eye discomfort may be altered, according to a recent study. “Clinicians should be aware that [Sjögren’s] patients may complain less of their discomfort” while having a particularly severe case…

Hospitalized patients with primary Sjögren’s syndrome (pSS) show an increased rate of specific cardiovascular concerns and sleep apnea syndrome (SAS), according to a study of a nationwide health insurance database in France. The cardiovascular issues include ischemic heart disease (heart disease associated with narrowed blood vessels) and pulmonary hypertension…

No connection is evident between exposure to the dental amalgam used to fill cavities and the risk of developing Sjögren’s syndrome,  a study by researchers in Taiwan reported. The study, “Analysis of dental amalgam fillings on primary Sjögren’s syndrome,” was published in Medicine.  Dental amalgam is…

A first patient has enrolled in a Phase 3 trial evaluating cenegermin in treating dry eye disease in people with Sjögren’s syndrome, marking the start of a two-part clinical study program, Dompé, the therapy’s developer, announced. The program will evaluate the safety and efficacy of…

Telitacicept (RC18), an experimental therapy being developed by RemeGen, significantly eased disease activity in people with primary Sjögren’s syndrome in a Phase 2 clinical trial, the company announced. “We are very excited to see the positive results from the Phase II clinical trial of telitacicept,” Jianmin Fang,…

Patients with primary Sjögren’s syndrome who experience symptoms such as pain, fatigue, and anxiety are more likely to show a decline in quality of life over time, according to a real-world study from the U.K. The study, “Primary Sjögren’s…

Punctal plugs, which are inserted into the tear ducts to keep the eyes lubricated, are a mainstay of treatment for dry eye in people with primary Sjögren’s syndrome, a South Korean study found. The approach may be combined with additional treatments, but appropriate therapies will depend on the presence…

Combining the anti-inflammatory medicines hydrocortisone and ciclosporin A could help ease eye symptoms in people with Sjögren’s syndrome, according to a new study. The study, “Efficacy of Topical Hydrocortisone in Combination with Topical Ciclosporin A for the Treatment of Dry Eye Disease in Patients with Sjögren…

The experimental oral therapy cenerimod prevented immune cells from entering the salivary glands and reduced gland inflammation in two Sjögren’s syndrome mouse models, a study demonstrated. “These encouraging data suggest that cenerimod may be a promising approach to treating Sjögren’s syndrome,” the scientists said. The study, titled “…