The anti-malaria medication artesunate could be a potential treatment of Sjögren’s syndrome, a study suggested. In mouse and cellular models, artesunate showed an ability to inhibit inflammatory T-helper 17 (Th17) cells and ease Sjögren’s symptoms. The study, “Artesunate suppresses Th17 response via inhibiting IRF4- mediated glycolysis…
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Memory complaints in people with primary Sjögren’s syndrome are linked to global cognitive impairment — problems affecting not only memory but also other mental faculties, according to data from a small study. While researchers noted that “associated psychiatric and sleep disorders greatly interfere” with cognition in Sjögren’s patients, they…
Ten new genetic regions, or loci, were found to be linked to an increased risk of Sjögren’s syndrome in people whose ancestry traces to Europe, according to a genome-wide association study (GWAS). These findings nearly double the total number of known risk loci from 12 to 22, in what…
An ultrasound evaluation of salivary gland damage may help the stratification of primary Sjögren’s syndrome patients and aid the design of future clinical trials, according to a recent study. The study, “Discriminative power of salivary gland ultrasound in relation to symptom-based endotypes in suspected and definite…
Higher-than-normal blood levels of uric acid, a body waste product, significantly raise the risk of hypertension among people with primary Sjögren’s syndrome (pSS), a study found. Findings suggest that monitoring uric acid levels may be one way to manage hypertension, or high blood pressure, to avoid cardiovascular problems arising later…
Self-targeting antibodies typically associated with a scarring disease called scleroderma are commonly found in people with Sjögren’s syndrome and may be useful in a diagnostic workup of those who have unexplained dryness of the eyes and mouth. That’s according to a study published in Seminars in Arthritis and Rheumatism…
From sharing personal stories and educating others, to raising funds for research, supporters globally are poised to mark World Sjögren’s Day — set aside each July 23 to heighten awareness of the chronic autoimmune disorder. Sjögren’s syndrome is thought to occur in approximately 0.1% to 4% of the general…
Alterations to immune dendritic cells in the eyes of people with Sjögren’s syndrome were associated with both bodywide and eye-related disease severity, a study reported. Using a non-invasive specialized microscope to examine these immune cells on the surface of the eyes might be an objective way of evaluating disease…
Levels of the inflammatory molecule IL-7 were higher in the blood of people with Sjögren’s syndrome compared with healthy people and were linked to greater disease severity and indicators of inflammation, a study found. A deeper review of literature relating to IL-7 and Sjögren’s across animal, cell cultures, and…
Magnetic resonance imaging (MRI) and ultrasounds can detect inflammation and lesions in the salivary glands that are suggestive of primary juvenile Sjögren’s syndrome (JSS) before dryness symptoms begin. These tests can help diagnose the disorder early, according to a recent case study that described the progression of JSS…
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