Marisa Wexler, MS, senior science writer —

Changes in the metabolic activity of certain immune cells may help to drive the inflammatory attacks that cause Sjögren’s syndrome, a recent study reported. According to its researchers, these findings suggest that targeting a specific metabolic pathway in immune cells, called aerobic glycolysis, may help to reduce disease activity…

Injecting the salivary glands with stem cells derived from fatty tissue was shown to ease the symptoms of Sjögren’s syndrome in a small clinical trial. “[Stem cell] therapy can provide relief of oral and eye’s dryness in our trial in a short time and has potential improvement of subjective…

Telitacicept, RemeGen’s experimental under-the-skin injection therapy, significantly reduced disease severity in adults with primary Sjögren’s syndrome (pSS), according to final data from a Phase 2 clinical trial. Results were detailed in the study “Efficacy and safety of telitacicept in primary Sjögren’s syndrome: a randomized,…

The case of a woman who was diagnosed with Sjögren’s syndrome after experiencing unusual symptoms, including hives and joint pain, was described in a recent report. “Our case highlights that rheumatological diseases do not always present with the typical clinical features and require a more detailed physical examination and…

Ultrasound evaluation of the salivary glands may be useful for diagnosing Sjögren’s syndrome, a new study reports. “Our results showed that [salivary gland ultrasound] may have a wide range of applications in the diagnosis of [Sjögren’s syndrome] due to its excellent interreader agreement and diagnostic performance,” researchers wrote. Ultrasound…

People with primary Sjögren’s syndrome (PSS) are at an increased risk of developing heart failure, heart attack, stroke, and other cardiovascular health problems compared with the general population, a new study reports. “The findings from our analysis could potentially have important clinical implications,” the researchers wrote. “Despite a low…

Vagus nerve stimulation (VNS), a procedure using a hand-held device to deliver electrical pulses to a nerve in the neck, eased fatigue for people with Sjögren’s syndrome in a small clinical trial. “Our data support further investigation into the role of [VNS] as a treatment for fatigue in patients with…

Sjögren’s syndrome is associated with a significantly increased risk of miscarriage and other adverse outcomes during pregnancy, a recent study reports. The study, “A meta-analysis of the effect of Sjögren’s syndrome on adverse pregnancy outcomes,” was published in the journal Clinics. Sjögren’s syndrome mainly affects…

Self-targeting antibodies typically associated with a scarring disease called scleroderma are commonly found in people with Sjögren’s syndrome and may be useful in a diagnostic workup of those who have unexplained dryness of the eyes and mouth. That’s according to a study published in Seminars in Arthritis and Rheumatism…

Steroid injections into the spine — similar to the epidural injections often given during childbirth — were effective in controlling pain as a result of nerve damage in a 32-year-old woman with Sjögren’s syndrome, according to a case report. The report, “Lumbar interlaminar epidural steroid injections…