Lindsey Shapiro, PhD, science writer —

Researchers have developed a quick, noninvasive way of collecting tear fluid and analyzing the proteins in it — an approach that could eventually be used to identify biomarkers that help to diagnose diseases affecting the eyes, including Sjögren’s syndrome. “We have successfully identified a sensitive approach for discerning the…

People with Sjögren’s syndrome may be at a higher risk of developing multiple types of cancer, according to a recent meta-analysis of several published studies. The analysis confirms a previously identified link between Sjögren’s and a type of blood cancer called non-Hodgkin lymphoma. It also highlighted new relationships between the…

A research team in Japan has developed three-dimensional (3D) “mini organs” from human stem cells to model the lacrimal glands, or tear ducts, which are dysfunctional in Sjögren’s syndrome. The first of their kind, these new mini organs, or organoids, can be used in the future to study disease…

Levels of the chemical messenger CCL28 are reduced in the blood of people with primary and secondary Sjögren’s syndrome, and were correlated with oral disease features like dental cavities and salivary gland damage, according to a recent Chinese study. Additionally, blood count changes — also lower — were linked…

Intense pulsed light therapy along with meibomian gland expression (IPL-MGX) significantly eased dry eye symptoms and improved eye health in people with Sjögren’s syndrome, according to a recent study.  “Our results indicated that three IPL-MGX sessions could significantly improve the subjective and objective…

NYU Langone Health is joining with a National Institutes of Health (NIH) sponsored program aimed at understanding disease mechanisms and developing new treatments for autoimmune disorders such as Sjögren’s syndrome. The program, called Accelerating Medicines Partnership Autoimmune and Immune-Mediated Diseases (AMP AIM), began last year in an…

Fatigue had the biggest impact on daily activities among people with primary Sjögren’s syndrome and was one of a number of symptoms associated with increased anxiety, depression, and physical limitations, according to a recent U.K. study. This effect was markedly reduced in patients with a longer disease duration, suggesting that…

Dry eye disease is more severe in people with primary Sjögren’s syndrome than in other patients, but their perception of eye discomfort may be altered, according to a recent study. “Clinicians should be aware that [Sjögren’s] patients may complain less of their discomfort” while having a particularly severe case…

A first patient has enrolled in a Phase 3 trial evaluating cenegermin in treating dry eye disease in people with Sjögren’s syndrome, marking the start of a two-part clinical study program, Dompé, the therapy’s developer, announced. The program will evaluate the safety and efficacy of…

Patients with primary Sjögren’s syndrome who experience symptoms such as pain, fatigue, and anxiety are more likely to show a decline in quality of life over time, according to a real-world study from the U.K. The study, “Primary Sjögren’s…