Rise Therapeutics plans to launch a Phase 1 clinical trial testing R-2487, its experimental oral therapy for autoimmune diseases, in people with Sjögren’s disease. R-2487, which leverages bacterial proteins to suppress the abnormal immune responses in autoimmune diseases like Sjögren’s, “is disease-modifying, focusing on long-term immune correction rather…
Immune B-cells that contain the receptor protein CD226 may play a role in the development and clinical manifestations of primary Sjögren’s disease, making CD226 a possible target for future treatments, a study reports. Data indicated that people with Sjögren’s had proportionally more CD226-positive B-cells in their bloodstream than their…
Levels of the receptor protein Mer tyrosine kinase (MerTK) in small salivary glands may be a useful marker for tracking disease activity and estimating tissue damage in Sjögren’s disease, a study reports. Researchers found that elevated MerTK, which plays a role in immune inflammation, was significantly associated with more…
The Sjögren’s Foundation is asking people to make a pledge to take action for World Sjögren’s Day on July 23 to help support the foundation’s research and education programs. Longtime Sjögren’s Foundation supporter Debby Vivari will donate $2 for the first 5,000 pledges and anyone can make a pledge…
Certain immune cell types are dysregulated in people with primary Sjögren’s disease, according to a new study from researchers in China that points to the resulting alterations as possible drivers of the condition and factors influencing its severity. “Our study demonstrates significant alterations in circulating immune cell populations in…
People with Sjögren’s disease tend to have poor oral health relative to the general population, despite generally good hygiene practices, a study found. Sjögren’s was associated with tooth decay, cavities, and wear, ultimately requiring more procedures to restore teeth. Hyposalivation, a common Sjögren’s disease symptom in which the…
People with Sjögren’s disease are at higher risk of developing non-Hodgkin lymphoma (NHL), a type of blood cancer, as well as other malignancies, a study reports. Researchers also identified several risk factors associated with cancer development in Sjögren’s patients, noting that nearly a quarter of deaths seen among…
Men with Sjögren’s disease show more early signs of lung and heart dysfunction than women and may be at an increased risk of developing pulmonary hypertension, a cardiovascular complication of Sjögren’s, a study reports. “As male patients demonstrated a greater predisposition to developing [pulmonary hypertension] … regular echocardiographic…
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