Anti-SSB antibodies may be a predictor of decreased lung function in people with primary Sjögren’s disease who also have interstitial lung disease (ILD), a group of conditions marked by inflammation and scarring in the lungs, according to a retrospective study from Romania. Particularly, the presence of these autoantibodies was…
More severe salivary gland damage and lymph node enlargement detected by ultrasound examination are associated with higher disease activity in primary Sjögren’s disease, a study in South Korea reports. Also, researchers found that more severe salivary gland damage was tied to a higher prevalence of laboratory risk factors for…
People with primary Sjögren’s disease diagnosed at a younger age and who harbor certain self-reactive antibodies are more likely to have kidney involvement, a study in South Korea suggests. While most with kidney involvement were asymptomatic, about a third had impaired kidney function when they were diagnosed and 25%…
More than half of women with Sjögren’s disease show loss of bone tissue, or bone erosion, according to a study carried out in Brazil. Findings also showed the volume of bone erosion increased by 7% per year, and was 3.5 times higher for women who had gone through menopause.
People with Sjögren’s disease who are positive for self-reactive, anti-SSA antibodies may develop more severe dry eye symptoms than those without anti-SSA and anti-SSB antibodies. That’s according to a study carried out in Mexico that also found patients with anti-SSA antibodies had significantly more signs of eye dryness associated…
People with primary Sjögren’s disease and neuropathic pain — pain caused by damage or dysfunction of the nervous system — are more likely to experience lower urinary tract problems than those without neuropathic pain. That’s according to a study in Turkey, which also found that neuropathic pain appeared to…
Ainos is partnering with Taiwan Tanabe Seiyaku, a subsidiary of Mitsubishi Tanabe Pharma, to advance the manufacturing and promotion of its investigational low-dose formulation of interferon alpha for Sjögren’s disease in Taiwan. Both parties will clarify the details of the partnership in a formal agreement. According to Ainos,…
Johnson & Johnson’s antibody-based therapy candidate nipocalimab has been granted breakthrough therapy designation by the U.S. Food and Drug Administration (FDA) for treating adults with moderate to severe Sjögren’s disease. This status is meant to accelerate the development and regulatory review of investigational therapies intended to treat serious…
Blood levels of antibodies against aquaporin 5 (anti-AQP5) — a protein that regulates water movement in tissues — may be used as a biomarker to diagnose primary Sjögren’s disease, a study…
Blood levels of transthyretin (TTR) may be used as a biomarker to predict and monitor disease activity in people with primary Sjögren’s disease, a study in China suggests. TTR is a protein that transports thyroxine, the main hormone secreted by the thyroid gland, to the liver and brain. It’s…
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