Johnson & Johnson’s antibody-based therapy candidate nipocalimab has been granted breakthrough therapy designation by the U.S. Food and Drug Administration (FDA) for treating adults with moderate to severe Sjögren’s disease. This status is meant to accelerate the development and regulatory review of investigational therapies intended to treat serious…
Blood levels of antibodies against aquaporin 5 (anti-AQP5) — a protein that regulates water movement in tissues — may be used as a biomarker to diagnose primary Sjögren’s disease, a study…
Blood levels of transthyretin (TTR) may be used as a biomarker to predict and monitor disease activity in people with primary Sjögren’s disease, a study in China suggests. TTR is a protein that transports thyroxine, the main hormone secreted by the thyroid gland, to the liver and brain. It’s…
KB-7898, Kronos Bio’s investigational therapy for Sjögren’s disease, was shown to lower antibody production and the release of inflammatory molecules in lab studies involving cell and animal models of autoimmune conditions, the company announced. Kronos is planning further preclinical studies to assess KB-7898’s safety and pharmacological properties…
An imaging test that measures damage to salivary glands may effectively be used, together with the presence of self-reactive antibodies, to diagnose Sjögren’s disease and determine disease staging. That’s according to a new study from China that investigated the use of the imaging test, called parotid sialography, alongside one…
Note: This story was updated Oct. 1, 2024, to clarify that Sjögren’s is a systemic disease, meaning it can affect moisture-producing glands, as well as other parts of the body. Ainos is planning to launch a Phase 3 clinical trial in Taiwan before the year’s end to evaluate the…
Lip salivary gland biopsy using an auxiliary device called chalazion forceps may diagnose primary Sjögren’s disease as accurately as the conventional method, but with fewer procedure-related complications, a study suggests. Researchers noted that, compared with the conventional method, “the modified [lip salivary gland biopsy] … offers a good safety…
Women with primary Sjögren’s syndrome are more likely to give birth prematurely and have babies born with congenital heart block (CHB) — a condition that disrupts the transmission of electrical signals within the heart needed to maintain a normal heartbeat — than women with other autoimmune conditions, a study…
Lip salivary gland biopsy may not be predictive of a Sjögren’s syndrome diagnosis, particularly when it’s based on tissue samples classified as showing a low level of inflammation and damage, according to a study. In 16% of the cases assessed in the study, different pathology teams would draw different conclusions…
World Sjögren’s Day is held every July 23, the birthday of Henrik Sjögren, the Swedish ophthalmologist who first identified Sjögren’s syndrome in 1933, and this year, to observe the 40th anniversary of the Sjögren’s Foundation, Amgen has pledged a dollar-to-dollar match up to $40,000, meaning donations supporting…
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